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Effects of diabetes type and treatment on zinc status in diabetes mellitus

  • Part 2: Trace elements in endocrinology
  • Section 3: Diabetes and Glucose Tolerance
  • Published:
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Abstract

Zinc status was assessed in 53 diabetic patients: 18 insulin-dependent diabetic patients (IDDM), 22 noninsulin-dependent diabetic patients (NIDDM) treated with oral antidiabetic agents, and 13 insulin-treated, noninsulin-dependent diabetic patients (IRDM). Plasma zinc concentrations were in the usual range for healthy subjects in these three groups (15.3±0.9 μmol/L). Urinary zinc excretions were elevated in the IDDM group (18.3±4.1 μmol/24 h;p<0.01 vs normal) and in the NIDDM group (17.5±3.5 μmol/24 h;p<0.01 vs normal), but normal in the IRDM group (11.3±2.4 μmol/24 h). In 14 NIDDM patients treated with transient continuous sc insulin injections, urinary zinc decreased from 16.5±2.2 μmol/24 h before insulin treatment to 11.5±0.3 μmol/24 h after insulin treatment without any modification in plasma zinc concentrations.

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Authors and Affiliations

  1. Service de Médecine Interne, Centre Hospitalier Lyon-Sud, 69310, Pierre Benite, France

    Jerome Honnorat, Christiane Broussolle & Jacques Orgiazzi

  2. Laboratoire Pharmaceutique de Biochimie, Toxicologie et Analyse des Traces, Hôpital Edouard Herriot, 69003, Lyon, France

    Michele Accominotti, Andree-Carole Fleuret & Jean-Jacques Vallon

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  1. Jerome Honnorat
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  2. Michele Accominotti
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  3. Christiane Broussolle
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  4. Andree-Carole Fleuret
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  5. Jean-Jacques Vallon
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  6. Jacques Orgiazzi
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Honnorat, J., Accominotti, M., Broussolle, C. et al. Effects of diabetes type and treatment on zinc status in diabetes mellitus. Biol Trace Elem Res 32, 311–316 (1992). https://doi.org/10.1007/BF02784616

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  • DOI: https://doi.org/10.1007/BF02784616

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