Abstract
The implications of essential trace elements in endocrinological processes, mainly thyroid function, growth, gonadal function, adrenal hormones, prolactin, glucose homeostasis, calcium-phosphorus metabolism, and thymulin activity, are reviewed. Most concerned elements in this field include iodine, zinc, selenium, copper, chromium, manganese and vanadium. The minerals are powerful modulators of several physiological functions that can be considerably perturbed in deficiency states. The resulting biochemical and clinical modifications can be prevented and/or corrected by adequate supplementation. Sometimes, however, they act like pharmacological agents when their beneficial effects are not the result of a correction of a nutritional deficiency state. Their potentialities as therapeutic agents are perfectly described in many cases, but some indications deserve further investigations.
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References
B. S. Hetzel, B. J. Potter, and E. M. Dulberg,The iodine deficiency disorders: nature, pathogenesis and epidemiology, World Rev. Nutr. Diet., vol. 62, G. H. Bourne, ed., Karger, Basel, 1990, pp. 60–119.
B. S. Hetzel and J. T. Dunn,Ann. Rev. Nutr. 9, 21 (1989).
F. Delange,Clin. Endocrinol. Metab. 2, 637 (1988).
F. Delange, P. Heidemann, P. Bourdoux, A. Larsson, R. Vigneri, M. Klett, C. Beckers, and P. Stubbe,Biol. Neonate 49, 322 (1986).
E. Frieden,Trends Biochem. Sci. 2, 50 (1981).
B. S. Hetzel and G. F. Maberly,Trace Elements in Human and Animal Nutrition, vol. 2, W. Mertz, ed., Academic, Orlando, 1986, pp. 139–208.
J. W. Oliver, D. Sachan, P. Su, and F. M. Applehans,Drug-Nutrient Int. 5, 113–124 (1987).
J. E. Morley, J. Gordon, and J. M. Hershman,Am. J. Clin. Nutr. 33, 1767 (1980).
D. Jordan, C. Suck, M. Veisseire, and G. Chazot,Hormone Res. 24, 263 (1986).
L. Wada and J. C. King,J. Nutr. 116, 1045 (1986).
G. Napolitano, G. Palka, S. Lio, I. Bucci, P. De Remigis, L. Stuppia, and F. Monaco,Ann. Génét. 33, 9 (1990).
K. Aihara, Y. Nishi, S. Hatano, M. Kihara, K. Yoshimitsu, N. Takeichi, T. Ito, H. Ezaki, and T. Usui,Am. J. Clin. Nutr. 40, 26 (1984).
K. Yoshida, Y. Kiso, W. Takao, K. Kaise, N. Kaise, Y. Itagaki, M. Yamamoto, T. Sakurada, and K. Yoshinaga,Metab. 39, 182 (1990).
J. Aaseth, H. Frey, E. Glattre, G. Norheim, J. Ringstad, and Y. Thomassen,Biol. Trace Elem. Res. 24, 147 (1990).
D. Behne, H. Hilmert, S. Scheid, H. Gessner, and W. Helger,Biochem. Biophys. Acta 966, 12 (1988).
P. Goyens, J. Golstein, B. Nsombola, H. Vis, and J. E. Dumont,Acta Endocrinol. 114, 497 (1987).
J. Nève, F. Vertongen, and L. Molle,Clin. Endocrinol. Metab. 14, 629 (1985).
G. J. Beckett, D. A. MacDougall, F. Nicol, and J. Arthur,Biochem. J. 259, 887 (1989).
G. J. Beckett, F. Nicol, D. Proudfoot, K. Dyson, G. Loucaides, and J. Arthur,Biochem. J. 266, 743 (1990).
J. Arthur and G. J. Beckett,Selenium in Biology and Medicine, A. Wendel, ed., Springer-Verlag, Berlin, 1989, pp. 90–95.
K. M. Hambidge, C. E. Casey, and N. Krebs,Trace Elements in Human and Animal Nutrition, vol. 2, W. Mertz, ed., Academic, Orlando, 1986, 1–37.
A. S. Prasad,Clin. Endocrinol. Metab. 14, 567 (1985).
P. A. Walravens, K. M. Hambidge, and D. M. Koepfer,Pediatr. 83, 532 (1989).
R. S. Gibson, P. Smit Vanderkooy, A. C. Macdonald, A. Goldman, B. A. Ryan, and M. Berry,Am. J. Clin. Nutr. 49, 1266 (1989).
S. Ghavami-Maibodi, P. Collipp, M. Castro-Magana, C. Stewart, and S. Chen,Ann. Nutr. Metab. 27, 214 (1983).
Y. Nishi, S. Hatano, K. Aihara, A. Fujie, and M. Kihara,J. Am. Coll. Nutr. 8, 93 (1989).
Z. T. Cossack,Brit. J. Nutr. 56, 1986 (1986).
C. J. McClain, J. S. Gavaler, and D. H. Van Thiel,J. Lab. Clin. Med. 104, 1007 (1984).
S. I. Salem, W. A. Coward, P. G. Lunn, and G. J. Hudson,Ann. Nutr. Metab. 28, 44 (1984).
M. Castro-Magana, P. J. Collipp, S. Chen, T. Cheruvanky, and V. Maddiah,Am. J. Dis. Child. 135, 322 (1981).
A. Favier and M. Favier,Rev. Franc. Gynecol. 85, 13 (1990).
L. Powell-Beard, K. Lei, and L. Shenker,Obstet. Gynecol. 69, 26 (1987).
J. H. Fishman and J. Fishman,Biochem. Biophys. Res. Commun. 152, 783 (1988).
E. Hazum,Biochem. Biophys. Res. Commun. 112, 306 (1983).
A. Flynn, W. H. Strain, and W. J. Porries,Biochem. Biophys. Res. Commun. 46, 1113 (1972).
K. H. Falchuk,N. Engl. J. Med. 296, 1129 (1977).
R. J. Cousins,Physiol. Rev. 65, 238 (1985).
A. Flynn, W. Pories, W. H. Strain, O. A. Hill, and R. Frantianne,Lancet 27, 1169 (1971).
A. Peretz, J. Nève, and J. P. Famaey,J. Trace Elem. Electrolytes Health Dis. 3, 103 (1989).
J. Fontaine, J. Nève, A. Peretz, F. Pelen, and J. P. Famaey,Int. J. Tiss. Reac. 11, 253 (1989).
J. Fontaine, J. Nève, A. Peretz, P. Capel, and J. P. Famaey,Agents Actions, in press (1991).
R. J. Cousins,Clin. Physiol. Biochem. 4, 20 (1986).
A. Peretz, J. Nève, J. P. Famaey, and L. Molle,J. Pharm. Belg. 42, 395 (1987).
E. Couturier, A. Van Onderbergen, D. Bosson, and J. Nève,J. Trace Elem. Electrolytes Health Dis. 2, 245 (1988).
A. Peretz, J. Nève, J. Fontaine, F. Vertongen, and J. P. Famaey,Selenium in Medicine and Biology, J. Nève and A. Favier, eds., Walter de Gruyter, Berlin-New York, 1989, pp. 93–96.
A. Peretz, J. Nève, F. Vertongen, J. P. Famaey, and L. Molle,J. Rheumatol. 14, 1103 (1987).
S. Mahajan, R. Hamburger, W. Flamenbaum, A. Prasad, and F. McDonald,Lancet 750, October 5, 1985.
M. Koppelman,Med. Hypoth. 25, 65 (1988).
M. Koppelman, V. Greenwood, J. Sohn, and P. Deuster,J. Clin. Endocrinol. Metab. 68, 215 (1988).
W. Kinlaw, A. Levine, J. Morley, S. Silvis, and G. McClain,Am. J. Med. 75, 273 (1983).
H. Roth and M. Kirchgessner,Biol. Trace Element Res. 3, 13 (1981).
M. Failla and C. Gardell,Proc. Soc. Exp. Biol. Med. 180, 317 (1985).
B. Hagglof, G. Hallmans, G. Holmgren, J. Ludvigsson, and S. Falkmer,Acta Endocrinol. 102, 88 (1983).
A. Sjorgren, L. Edvinsson, C. Floren, and M. Abdulla,Nutr. Res. 6, 147 (1986).
E. Offenbacher and F. X. Pi-Sunyer,Ann. Rev. Nutr. 8, 543 (1988).
R. Anderson,Sci. Total Environ. 86, 75 (1989).
R. Anderson, M. Polansky, N. Bryden, S. Bhatena, and J. Canary,Metabolism 36, 351 (1987).
R. Anderson,Essential and Toxic Trace Elements in Human Health and Disease, Alan R. Liss, New York, 1988, pp. 189–197.
S. Wallach,J. Am. Coll. Nutr. 4, 107 (1985).
W. Mertz, E. Morris, J. C. Smith, E. Udomkesmalee, M. Fields, O. Levander, and R. Anderson,Nutrition, Aging and the Elderly, H. Munro and D. Danford, eds., Plenum, New York, 1989, pp. 195–244.
A. H. Rubenstein, N. W. Levin, and G. A. Elliott,Lancet, 1348 (1962).
M. Korc,Essential and Toxic Trace Elements in Human Health and Disease, Alan R. Liss, New York, 1988, pp. 253–273.
J. L. Domingo, J. Llobet, M. Gomez, J. Corbella, and C. L. Keen,Metal Ions in Biology and Medicine, P. Collery, ed., John Libbey, Paris, 1990, pp. 312–314.
S. M. Brichard, W. Okitolonda, and J. C. Henquin,Endocrinology 123, 2048 (1988).
O. Blondel, D. Baible, and B. Ortha,Diabetologia 32, 185 (1989).
Anonymous,Nutr. Rev. 36, 152 (1978).
T. Gunther, V. Hollriegl, and J. Vormann,Biol. Trace Elem. Res. 16, 129 (1988).
H. P. Roth and M. Kirchgessner,J. Trace Elem. Electrolytes Health Dis 3, 225 (1989).
B. L. Riggs, E. Seeman, S. Hodgson, D. R. Taves, and O. O'Fallon,N. Engl. J. Med. 306, 446 (1985).
D. S. Bernstein, N. Sadowski, D. Hegsted, C. Guri, and F. Stare,JAMA 198, 499 (1966).
B. L. Riggs, S. Hodgson, W. N. O'Fallon, E. Y. S. Chao, H. W. Wahner, J. N. Muhs, S. L. Cedel, and L. J. Melton III,N. Engl. J. Med. 322, 802 (1990).
A. S. Prasad, S. Meftah, J. Abdallah, J. Kaplan, G. Brewer J. Bach, and M. Dardenne,J. Clin. Invest. 82, 1202 (1988).
B. Jambon, O. Ziegler, B. Maire et al.,Am. J. Clin. Nutr. 48, 335 (1988).
C. Franceschi, M. Chiricolo, F. Licastro, M. Zannotti, M. Masi, E. Mocchegiani, and N. Fabris,J. Ment. Defic. Res. 32, 168 (1988).
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Neve, J. Clinical implications of trace elements in endocrinology. Biol Trace Elem Res 32, 173–185 (1992). https://doi.org/10.1007/BF02784602
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DOI: https://doi.org/10.1007/BF02784602