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Physiological chromium determination in serum by zeeman graphite furnace atomic absorption spectrometry

A serious challenge

  • Part 1: Chromium
  • Section 1: Biological Status and Nutritional Aspects
  • Published:
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Abstract

Several authors have already underlined chromium implication in glucose and lipids metabolism of humans. In this field, physiological chromium determination in serum could be helpful, but the discrepancies reported in numerous papers are confusing. Here we report some results obtained by Zeeman correction Graphite Furnace Atomic Absorption Spectrometry: This technique includes a dilution of serum with 12.5 mM ultrapure nitric acid and 0.25% Triton X-100 (final concentrations). Some main features can be outlined: (1) the contamination constitutes a serious drawback and (2) the sensitivity of the technique is critical (characteristic mass found: 1.76 pg/0.0044 A.s). Our results obtained from 27 healthy subjects (2.01±0.77 nmol/L) agree with most recent studies and indicate that serum chromium level does not seem to be sex-related.

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Authors and Affiliations

  1. Laboratoire Central de Biochimie, Hôpital Lariboisière, 2, rue A. Paré, 75010, Paris, France

    Philippe Chappuis, Joël Poupon & François Rousselet

  2. Laboratoire d'Hémobiologie-Transfusion, Hôpital lariboisière, 2, rue A. Paré, 75010, Paris, France

    Jeanne-Françoise Deschamps

  3. Service de Médecine Interne, Hôpital Lariboisière, 2, rue A. Paré, 75010, Paris, France

    Pierre-Jean Guillausseau

Authors
  1. Philippe Chappuis
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  2. Joël Poupon
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  3. Jeanne-Françoise Deschamps
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  4. Pierre-Jean Guillausseau
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  5. François Rousselet
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Chappuis, P., Poupon, J., Deschamps, JF. et al. Physiological chromium determination in serum by zeeman graphite furnace atomic absorption spectrometry. Biol Trace Elem Res 32, 85–91 (1992). https://doi.org/10.1007/BF02784591

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  • DOI: https://doi.org/10.1007/BF02784591

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