Biological Trace Element Research

, Volume 53, Issue 1–3, pp 65–83 | Cite as

Selenium-vitamin E supplementation in infertile men

Effects on semen parameters and micronutrient levels and distribution
  • Denis Vézina
  • François Mauffette
  • Kenneth D. Roberts
  • Gilles Bleau
Original Articles


In order to verify the hypothesis that selenium (Se) and vitamin E (Vit E) could improve male fertility, nine oligoasthenoteratozoospermic men were supplemented for a period of 6 mo with Se and Vit E. Compared to the baseline period (presupplementation) of 4 mo, statistically significant increases were observed for Se and Vit E levels, sperm motility, percent live, and percent normal spermatozoa. These improvements are likely to be “supplementation-dependent,” since all of the parameters returned to baseline values during the posttreatment period. None of the couples reported a pregnancy during the study. The HPLC analysis conducted on the serum of one of the patients showed the existence of at least six different Se-containing peaks, whose Se content was affected by supplementation. The mechanism(s) involved in these improvements of semen parameters is presently under investigation.

Index Entries

Selenium vitamin E infertility 


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Copyright information

© Humana Press Inc. 1996

Authors and Affiliations

  • Denis Vézina
    • 1
    • 5
  • François Mauffette
    • 2
    • 4
  • Kenneth D. Roberts
    • 3
    • 5
  • Gilles Bleau
    • 1
    • 5
  1. 1.Department of Obstetrics and GynecologyUniversity of MontrealMontrealCanada
  2. 2.Department of MedicineUniversity of MontrealMontrealCanada
  3. 3.Department of BiochemistryUniversity of MontrealMontrealCanada
  4. 4.St-Luc HospitalMontrealCanada
  5. 5.Maisonneuve-Rosemont Research CenterMontrealCanada

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