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Changed serum trace element profile in Down's syndrome

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Abstract

Being cofactors of important antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx), which are significantly modified in Down's syndrome (trisomy 21), serum levels of microtrace elements zinc, copper, and selenium and of macroelement magnesium are reported in 16 subjects with Down's syndrome (DS) and their respective well age- and sex-matched controls. Serum zinc and selenium levels were significantly lowered in DS subjects, whereas copper levels were elevated. Consequently, a marked increase (40%) of the copper/zinc ratio in DS persons was observed. There were no differences in serum levels of magnesium between DS and control subjects.

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References

  1. F. Licastro, M. C. Morini, and L. J. Davis,Pharmacol. Aging Processes 717, 299–306 (1994).

    CAS  Google Scholar 

  2. Y. H. Tan, J. Tischfield, and F. H. Ruddle,J. Exp. Med. 137, 317–330 (1973).

    Article  PubMed  CAS  Google Scholar 

  3. P. M. Sinet, A. Michelson, A. Bazin, J. Lejeune, and H. Jerome,Biochem. Biophys. Res. Commun. 67, 904–909 (1975).

    Article  PubMed  CAS  Google Scholar 

  4. A. Baret, M. A. Baetman, J. F. Mattei, P. Michel, B. Brousolle, and F. Giraud,Biochem. Biophys. Res. Commun. 98, 1035–1043 (1981).

    Article  PubMed  CAS  Google Scholar 

  5. L. Gilles, C. Ferradini, J. Foos, J. Pucheault, D. Allard, P. M. Sinet, and H. Jerome,FEBS Lett. 69, 55–58 (1976).

    Article  PubMed  CAS  Google Scholar 

  6. M. E. Percy, A. J. Dalton, V. D. Markovic, D. R. Crapper McLachlan, J. T. Hummel, A. C. M. Rusk, and D. F. Andrews,Am. J. Med. Gen. 35, 459–467 (1990).

    Article  CAS  Google Scholar 

  7. B. W. L. Brooksbank, and P. Balasz,Dev. Brain Res. 16, 37–44 (1984).

    Article  CAS  Google Scholar 

  8. B. Björksen, O. Back, K. Gustavson, G. Haumans, B. Haglof, and A. Tarvnik,Acta Paediatr. Scand. 69, 1983–1987 (1981).

    Google Scholar 

  9. A. Madáriĉ, J. Kadrabová, and E. Ginter,J. Trace Elem. Electrolytes Health Dis. 8, 43–47 (1994).

    PubMed  Google Scholar 

  10. J. Neve, P. M. Sinet, L. Molle, and A. Nicole,Clin. Chem. Acta 133, 209–214 (1983).

    Article  CAS  Google Scholar 

  11. F. Licastro, M. Chiricolo, M. Mocchegiani, N. Fabris, M. Zannoti, E. Beltrandi, R. Mancini, R. Parente, G. Arena, and M. Masi,J. Intellect. Disabil. Res. 38, 149–162 (1994).

    Article  PubMed  Google Scholar 

  12. F. Licastro, E. Mocchegiani, M. Masi, and N. Fabris,J. Trace Elem. Electrolytes Health Dis. 7, 237–239 (1993).

    PubMed  CAS  Google Scholar 

  13. G. Napolitano, G. Palka, S. Grimaldi, C. Guiliano, G. Laglia, G. Calabrese M. A. Satta, G. Neri, and F. Monaco,Am. J. Med. Genet. Suppl. 7, 63–65 (1990).

    Article  PubMed  CAS  Google Scholar 

  14. T. M. Bray and W. J. Bettger,Free Radical. Biol. Med. 8, 281–291 (1990).

    Article  CAS  Google Scholar 

  15. C. Franceschi, C. M. Chiricolo, F. Licastro, M. Zannoti, M. Masi, E. Mocchegiani, and N. Fabris,J. Ment. Defic. Res. 32, 169–181 (1988).

    PubMed  Google Scholar 

  16. T. Westermarck, E. Antila, E. Johansson, U. Lindh, and U. R. Nordberg,J. Trace Elem. Electrolytes Health Dis. 7, 125–126 (1993).

    Google Scholar 

  17. A. Mad'ariĉ, E. Ginter, and J. Kadrabová,Physiol. Res. 43, 107–111 (1994).

    Google Scholar 

  18. F. Licastro, M. C. Morini, M. Chiricolo, R. Conte, D. Belletti, R. Mancini, E. Beltrandi, M. Casadei-Maldini, and E. Carpene,J. Trace Elem. Electrolytes Health Dis. 7, 234–236 (1993).

    PubMed  CAS  Google Scholar 

  19. T. Takeda, Proceedings of the First International Conference on senescence: The SAM model, Kyoto, 17–18 March, pp. 317–320 (1994).

  20. R. Delonce, O. Guillard, P. Turq, and N. Pruliere, inMetal Ions in Biology and Medicine, Ph. Collery, L. A. Poirier, M. Manfait, and J. C. Etienne, eds., Eurotext, Paris, pp. 336–338 (1990).

    Google Scholar 

  21. I. Semsei, F. Jeney, and T. Fülöp,Arch. Gerontol. Geriatr. 17, 123–130 (1993).

    Article  PubMed  CAS  Google Scholar 

  22. D. Harmand,J. Gerontol. 11, 289–300 (1956).

    Google Scholar 

  23. P. M. Sinet, J. Neve, A. Nicole, and L. Molle,Acta Paediatr. Scand. 73, 275–277 (1984).

    PubMed  CAS  Google Scholar 

  24. G. Annaren, C. G. M. Magnusson, and S. L. Nordvall,Arch. Dis. Childhood 65, 1353–1355 (1990).

    Article  Google Scholar 

  25. G. Annaren, M. Gebre-Medhin, and K. H. Gustavson,Acta Paediatr. Scand 78, 879–884 (1989).

    Google Scholar 

  26. J. R. Arthur, F. Nicol, and G. J. Beckett,Am. J. Clin. Nutr. 57 (Suppl. 1), 236S-239S (1993).

    PubMed  CAS  Google Scholar 

  27. Z. Zhu, M. Kimura, and Y. Itokawa,Biol. Trace Elem. Res. 37, 209–217 (1992).

    Google Scholar 

  28. H. H. Bruhl, J. Foni, H. Lee, and A. Madow,Am. J. Ment. Defic. 92, 103–111 (1987).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Preventive and Clinical Medicine, Limbová 14, 833 01, Bratislava, Slovak Republic

    Jana Kadrabová, Alexander Madáriĉ, Mária Šustrová & Emil Ginter

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  1. Jana Kadrabová
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  2. Alexander Madáriĉ
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  3. Mária Šustrová
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  4. Emil Ginter
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Kadrabová, J., Madáriĉ, A., Šustrová, M. et al. Changed serum trace element profile in Down's syndrome. Biol Trace Elem Res 54, 201–206 (1996). https://doi.org/10.1007/BF02784431

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  • DOI: https://doi.org/10.1007/BF02784431

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