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Effect of aluminum on superoxide dismutase activity in the adult rat brain

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Abstract

Male rats were treated daily with an intraperitoneal injection of 15 mg aluminum (Al chloride)/kg body weight for 17 d, in order to study the effects on superoxide dismutase (SOD) activities in the brain (cortex). No significant difference between control and treated animals was registered in the Cu/Zn and Mn SOD activities in the gray matter of the cortex. High Al levels were found in the plasma, the spleen, and the liver of the treated animals in comparison to the controls, but not in the cortex homogenates (gray matter). In addition, Al induced a significant decrease in food ingestion and weight gain.

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Authors and Affiliations

  1. University of Plymouth Plymouth Environmental Research Centre (PERC), Biological Sciences, Drake Circus, Plymouth, PL4, 8AA, Devon, UK

    F. Atienzar

  2. Laboratoire de Biologie et Physiologie du Comportement, URA CNRS 1293, Faculté des Sciences, Université Henri Poincaré, Nancy I, 54500 Vandoeuvre les Nancy Cédex, France

    D. Desor & P. Lehr

  3. Service de Chimie Générale Appliquée à la Médecine, Université Henri Poincaré, Nancy I, 54500 Vandoeuvre les Nancy Cédex, France

    D. Burnel

  4. Laboratoire de Biologie Cellulaire du Développement, Faculté des Sciences, Université Henri Poincaré, Nancy I, 54500 Vandoeuvreles Nancy Cédex, France

    J. M. Keller

  5. Centre des Sciences de l’Environnement, Université de Metz, 1 rue des Récollets, 57000 Metz, France

    F. Atienzar, P. Lehr & P. Vasseur

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  1. F. Atienzar
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  2. D. Desor
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Atienzar, F., Desor, D., Burnel, D. et al. Effect of aluminum on superoxide dismutase activity in the adult rat brain. Biol Trace Elem Res 65, 19–30 (1998). https://doi.org/10.1007/BF02784111

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  • DOI: https://doi.org/10.1007/BF02784111

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