Abstract
Ureteral ligation causes tubulointerstitial nephropathy characterized by the tubular dilatation, the interstitial expansion, and a leukocyte infiltration into the tubulointerstitium. The present study was designed to explore whether zinc (Zn) deficiency affects the development of unilateral ureteral obstruction (UUO)-induced tubulointerstitial nephropathy. Compared to rats fed a standard diet, rats fed a Zn-deficient diet exhibited a greater influx of leukocytes into the tubulointerstitium of the cortex of the obstructed kidney 3 d following UUO. Furthermore, rats fed a Zn-deficient diet showed a slight invasion of leukocytes into the tubulointerstitium of the cortex of the contralateral nonobstructed kidney (CLK), although there was no infiltration of leukocytes into the CLK of rats fed a standard diet. These histological changes, however, were ameliorated by administration of enalapril, an angiotensin (ANG) I-converting enzyme inhibitor. Thus, it is suggested that Zn deficiency aggravates UUO-induced tubulointerstitial nephropathy via an increase in the action of ANG II.
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References
G. F. Schreiner, K. P. G. Harris, M. L. Purkerson, and S. Klahr, Immunological aspects of acute ureteral obstruction: Immune cell infiltrate in the kidney,Kidney Int. 34, 487–493 (1988).
A. Reyes, J. Lefkowith, J. Pippin, and S. Klahr, Role of the 5-lipoxygenase pathway in obstructive nephropathy,Kidney Int. 41, 100–106 (1992).
H. Kaneto, J. Morrissey, R. McCracken, A. Reyes, and S. Klahr, Enalapril reduces collagen type IV synthesis and expansion of the interstitium in the obstructed rat kidney,Kidney Int. 45, 1637–1647 (1994).
S. Ishidoya, J. Morrissey, R. McCracken, A. Reyes, and S. Klahr, Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction,Kidney Int. 47, 1285–1294 (1995).
P. G. Reeves and K. L. Rossow, Zinc deficiency affects the activity and protein concentration of angiotensin-converting enzyme in rat testes,Proc. Soc. Exp. Biol. Med. 203, 336–342 (1993).
D. Yoshida, Y. Ikeda, and S. Nakazawa, Suppression of 9L gliosarcoma growth by copper depletion with copper-deficient diet and D-Penicillamine,J Neuro-Oncol. 17, 91–97 (1993).
H. Yanagisawa, J. Morrissey, A. R. Morrison, and S. Klahr, Eicosanoid production by isolated glomeruli of rats with unilateral ureteral obstruction,Kidney Int. 37, 1528–1535 (1990).
H. Yanagisawa, J. Morrissey, N. Kurihara, O. Wada, and S. Klahr, Effects of dietary protein on glomerular eicosanoid production in rats with bilateral ureteral obstruction,Proc. Soc. Exp. Biol. Med. 207, 234–241 (1994).
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Yanagisawa, H., Nodera, M. & Wada, O. Zinc deficiency aggravates tubulointerstitial nephropathy caused by ureteral obstruction. Biol Trace Elem Res 65, 1–6 (1998). https://doi.org/10.1007/BF02784109
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DOI: https://doi.org/10.1007/BF02784109