Abstract
The Cu and Zn levels of both 607 men (1–85 y old) and 649 women (1–92 y old) were determined by atomic absorption spectrometry. Sex does not influence Cu (14.89±0.89 μg/g and 15.26±0.79 μg/g hair for males and females, respectively) and Zn contents (200.97±9.68 μg/g for men and 209.81±9.49 μg/g hair for women). Age influences Cu and Zn concentrations, but only significantly in females: Cu levels decrease over 60 y of age; whereas Zn levels increase significantly from age groups 2–5 to 20–40 years. Hair color influences Cu concentrations in both males and females. In males, white hair containes less Cu than black hair; in females, white hair's Cu levels are significantly lower than those of dark blond, red, light brown, and brown hair. There are no significant differences in Zn concentrations with respect to different hair colors, in either males or females.
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T. H. Maugh, Hair: a diagnostic tool to complement blood serum and urine,Science 202, 1271 (1978).
D. C. Hilderbrand, and D. H. White, Trace-element analysis in hair an evaluation,Clin. Chem. 20, 148–151 (1974).
A. Taylor, Usefulness of measurements of trace elements in hair,Ann. Clin. Biochem. 23, 364–378 (1986).
V. Valkovic,Human Hair: Trace-Element Levels, vol. 2, CRC, Boca Raton, FL, pp. 207 (1988).
G. M. Martin, Copper content of hair and nails of normal individuals and of patients with hepatolenticular degeneration,Nature 202, 903–904 (1964).
D. Ya. Shabel'nik, Relationship between the colour of the hair, sex, and the hair microelement content,Sud. Med. Epert. 9, 7–9 (1966).
D. Ya. Shabel'nik, Trace element levels in human hair in relation to sex and age,Mikroelem. Med. 1, 184 (1968).
H. A. Schroeder and A. P. Nason, Trace metals in human hair,J. Invest. Dermatol. 53, 71–78 (1969).
L. M. Klevay, Hair as a biopsy material. II. Assessment of copper nutriture,Am. J. Clin. Nutr. 23, 1194–1202 (1970).
M. H. Briggs, M. Briggs, and A. Wakatama, Trace elements in human hair,Experientia 28, 406–407 (1972).
J. P. Creason, T. A. Hinners, J. E. Bumgarner, and C. Pinkerton, Trace elements in hair, as related to exposure in metropolitan New York,Clin. Chem. 21, 603–612 (1975).
S. Yamada, M. Oka, M. Fukuda, and T. Miyazaki, Trace metal contents in scalp hair of people in Osaka City,Seikatsu Eisei 22, 26–31 (1978).
S. B. Deeming and C. W. Weber, Hair analysis of trace minerals in human subjects as influenced by age, sex, and contraceptive drugs,Am. J. Clin. Nutr. 31, 1175–1180 (1978).
D. M. Burke, F. J. DeMicco, L. J. Taper, and S. J. Ritchey, Copper and zinc utilization in elderly adults,J. Gerontol. 36, 558–563 (1981).
X. Wang, X. Xia, Z. Chen, Y. Xu, Z. Shi, and J. Wu, Determination of trace elements in normal hair by radioisotope-excited X-ray fluorescence,Huanjing Kezue 2, 341–343 (1981).
Z. Chen, X. Wang, W. Yu, M. Huang, D. Huang, G. Liang, L. Shen J. Zhang, and R. Xia, Preliminary study of calcium and some trace elements in hair of people in Shanghai and Nanjing, China,Yinhgyang Xuebao 5, 275–283 (1983).
M. Kamakura, A study of the characteristics of trace elements in the hair of Japanese,Nippon Eiseigaku Zasshi 38, 823–838 (1983).
T. Inoue and T. Maitani, Copper and zinc in human hair and blood,Kyoto-fu Eisei Kogai Kenkyusho Nenpo 29, 55–58 (1984).
W. Chen and Y. Xie, Zinc, copper, and iron contents of hair in different ages and sexes of children and adolescents,Yingyang Xuebao 9, 270–273 (1987).
H. Uchida, K. Takahashi, H. Toyoda, J. Takahashi, A. Sugahara, H. Tomita, and H. Omori, Studies on the characteristics of trace metals in the scalp hair of Japanese,Biryo Kinzoku Taisha XX, 103–108 (1987).
B. Cao, L. Quiao, M. Zhang, and Lihua Jianyan, Spectrophotometric determination of microamounts of copper in hair,Huaxue Fence 24, 306 (1988).
S. Han, B. Xie, G. Wang, R. Cai, and J. Li, The contents of seven trace elements and magnesium in hair and serum of children in Wuhan,Yingyang Xuebao 10, 150–157 (1988).
C. Costa, R. Arban, and G. Allegri, Correlation between age, sex and colour and hair levels of copper and zinc. A premise for studies on human pigmentation disorders,Giorn. It. Chim. Clin. 14, 73–76 (1989).
Y. Sha, P. Liu, R. Zhang, G. Liu, Z. Zhang, Y. Feng, G. Liu, G. Sun, and S. Wang, Determination of trace elements in hair of Wilson's disease patients using PIXE,Nucl. Instrum. Methods Phys. Res., Sect. B 22, 191–192 (1987).
H. G. Petering, D. W. Yeager, and S. O. Witherup, Trace metal content of hair. I. Zinc and copper content of human hair in relation to age and sex,Arch. Environ. Health 23, 202–207 (1971).
R. S. Gibson, and M. S. DeWolfe, The zinc, copper, manganese, vanadium and iodine content of hair from 38 Canadian neonates,Pediatr. Res. 13, 959–962 (1979).
M. Huang, G. Liang, D. Huang, L. Shen, Y. Xu, J. Zhang, Z. Xiang, Z. Wang, Z. Chen, and W. Yu, Preliminary observation on trace elements in the hair of the elderly,Zhonghua Yixue Zazhi 62, 134–137 (1982).
R. S. Gibson, The trace metal status of some Canadian full-term and low-birth-weight infants at one year of age,J. Radioanal. Chem. 70, 175–189 (1982).
E. Kauf, W. Wiesener, and S. Niese, Neutron activation analytical determination of zinc, copper, manganese, and gold in human hair during the first years of life,Isotopenpraxis 20, 138–141 (1984).
P. D. S. Vanderkooy and R. S. Gibson, Food consumption patterns of Canadian preschool children in relation to zinc and growth status,Am. J. Clin. Nutr. 45, 609–616 (1987).
N. Heinersdorff and T. G. Taylor, Concentration of zinc in the hair of schoolchildren,Arch. Dis. Child. 54, 958–960 (1979).
J. M. McKenzie, Content of zinc in serum, urine, hair, and toenails of New Zealand adults,Am. J. Clin. Nutr. 32, 570–579 (1979).
M. J. O'Leary, L. J. Mata, and P. V. J. Hegarty, Hair zinc levels in rural Costa Rican infants and preschool children,Am. J. Clin. Nutr. 33, 2194–2197 (1980).
M. Naplatarova, T. Karatoteva, G. Todorov, V. Peneva, and E. Deneva, Normal content of some chemical elements in the hair,Dermatol. Venerol. (Sofia)19, 102–105 (1980).
G. Allegri, C. Costa, M. Biasiolo, R. Arban, A. Bertazzo, and E. L. Cardin De Stefani, Tryptophan, copper and zinc in hair of healthy subjects. Correlation with differences in hair pigmentation,It. J. Biochemistry 39, 209–215 (1990).
P. S. Gentile, M. J. Trentalange, and M. Coleman, The relationship of hair zinc concentrations to height, weight, age, and sex in the normal population,Pediatr. Res. 15, 123–127 (1981).
B. Forshind, H. K. Li, K. G. Malmqvist, and D. Wiegleb, Elemental analysis of hair fibers using PIXE- a population study of sulfur and zinc content,Sci. Total Environ. 42, 219–222 (1985).
Z. Zhou, Z. Zhao, L. Feng, J. Ge, L. Jiang, and S. Zhu, Determination of hair zinc content in young adults by atomic absorption spectrometry,Zhejiang Yike Daxue Xuebao 15, 18–19 (1986).
H. Jiang, G. Han, Y. Zhang, X. Yu, L. Cong, H. Zhang, G. Liu, Q. Shao, and W. Guo, The study of zinc value in the hair of school-aged children in Jinan,Shandong Yike Daxue Xuebao 25, 54–57 (1987).
E. Kauf, W. Wiesener, and I. Sander, Der Gehalt der Spurenelemente Zn, Cu, Mn, Au, im Haar von 41 Jenaer Neugeborenen,Zenthralbl. Pharm. 121, 437 (1982).
E. Kauf, W. Wiesener, and S. Niese, Der Zink-, Kupfer-, Mangan-, und Goldehalt des Haares in den ersten Lebensjahren,Tag. Nukl. Analys. 3, 11 (1983).
R. Laitinen, E. Vuori, and H. K. Akerblom, Hair zinc and copper: relationship to hair type and serum concentrations in children and adolescents,Biol. Trace. Elem. Res. 16, 227–237 (1988).
D. C. Paschal, E. S. DiPietro, D. L. Phillips, and E. W. Gunter, Age dependence of metals in hair in a selected U.S. population,Environ. Res. 48, 17–28 (1989).
M. A. H. Eltayeb and R. E. Van Grieken, Iron, copper, zinc and lead in hair from sudanese populations of different age groups,Sci. Total Environ. 95, 157–165 (1990).
T. F. Dutcher and S. Rothman, Iron, copper, and ash content of human hair of different colors,J. Invest. Dermatol. 17, 65–68 (1951).
Z. Kikkawa, Z. Ogita, and S. Fujito, Nature pigments derived from tyrosine and tryptophan in animals,Science 121, 43–47 (1955).
H. Goss and M. M. Green, Copper in hair,Science 122, 330–331 (1955).
N. W. H. Addink and L. J. P. Frank, Zinc content of hair from the head of carcinoma patients,Nature 193, 1190–1191 (1962).
C. M. Lea and V. A. S. Luttrell, Copper content of hair in Kwashiorkor,Nature 206, 413 (1965).
D. Ya. Shabel'nik, Levels of trace elements in children's hair,Mikroelem. Med. 3, 94 (1972).
A. Sturaro, G. Parvoli, L. Doretti, S. Zanchetta, and G. Allegri, Simultaneous determination of trace metals in human hair by dynamic ion-exchange chromatography,Anal. Chim. Acta 274, 163–170 (1993).
A. Sturaro, G. Parvoli, L. Doretti, G. Allegri, and C. Costa, The influence of color, age, and sex on the content of zinc, copper, nickel, manganese, and lead in human hair,Biol. Trace Elem. Res. 40, 1–8 (1994).
W. H. Strain, W. J. Pories, A. Flynn, and O. A. Hill, Trace element nutriture and metabolism through head hair analysis,Trace Substances Environ. Health 5, 383 (1971).
W. W. Harrison, J. P. Yurachek, and C. A. Benson, The determination of trace elements in human hair by atomic absorption spectroscopy,Clin. Chim. Acta 23, 83–91 (1969).
M. Leotsinidis and X. Kondakis, Trace metals in scalp hair of Greek agricultural workers,Sci. Total Environ. 95, 149–156 (1990).
L. M. Klevay, Hair as a biopsy material. I. Assessment of zinc nutriture,Am. J. Clin. Nutr. 23, 284–289 (1970).
K. Akrida Demertzi, P. Demertzis, and A. Evangelou, Zinc concentration in plasma, serum and hair of healthy persons,Chem. Chron. 14, 111–116 (1985).
R. Moro, G. Gialanella, Y. X. Zhang, L. Perrone, and R. Di Toro, Trace elements in fullterm neonate hair,J. Trace Elem. Electrolytes Health Dis. 6, 27–31 (1992).
E. W. Rice and N. P. Goldstein, Cu content of hair and nails in Wilson's disease,Metab. Clin. Exp. 10, 1085 (1961).
M. Folin, E. Contiero, and I. Calliari, Quantitative determination of copper and zinc in biological samples (human hair): comparison between atomic absorption spectrometry and X-ray fluorescence spectrometry,Ann. Chim. 881, 39–49 (1991).
H. J. Schneider and M. Anke, Mineral content in human scalp hair, depending on age,Proc. 7th Int. Congr. Gerontol. 2, 29–31 (1966).
K. M. Hambidge, and W. Droegemueller, Changes in plasma and hair concentrations of zinc, copper, chronium, and manganese during pregnancy,Obstet. Gynecol. 44, 666 (1974).
K. Radomska, A. Graczyk, J. Konarski, and B. Adamowicz, Macro- and microelement content in the human body determined by the analysis of hair,Pol. Tyg. Lek. 46, 461 (1991).
M. Anke and H. J. Schneider, Untersuchungen uber den Mineralstoffgehalt der Frauen- und Mannerhaare,Dtsch. Z. Verdau. Stoffwechselkr. 22, 31–35 (1962).
M. V. Rajendran and A. Devaraj, The role of copper in the growth and greying of South Indian human hair,J. Curr. Biosci. 3, 90–91 (1986).
J. Horcicko, J. Borovansky, and J. Duchon, Verteilung von Zink und Kupfer in memschlichen Kopfhaar verschiedener Farbtone,Derm. Msch. 159, 206–209 (1973).
J. Erten, A. Arcasoy, A. O. Çavdar, and S. Cin, Hair zinc levels in healthy and malnourished children,Am. J. Clin. Nutr. 31, 1172–1174 (1978).
J. G. Dorea, I. S. Almeida, E. F. O. Queiroz, and M. R. Horner, Nutritional status and zinc nutriture in a poor urban community of Brazil,Ecol. Food Nutr. 12, 1–6 (1982).
J. G. Dorea, M. R. Horner, V. L. Bezerra, M. G. Pereira, and J. B. Salomon. Hair zinc levels and nutritional status in urban children from Ilheus, Bahia, Brazil,Human Nutr.: Appl. Nutr. 36A, 63–67 (1982).
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Bertazzo, A., Costa, C., Biasiolo, M. et al. Determination of copper and zinc levels in human hair. Biol Trace Elem Res 52, 37–53 (1996). https://doi.org/10.1007/BF02784088
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DOI: https://doi.org/10.1007/BF02784088