Abstract
The in vitro effects of a trace element preparation (Béres Drops Plus, BDP) on the biosynthesis of inflammatory cytokines interleukin (IL)-6, IL-1, and tumor necrosis factor-alpha (TNF-α) were studied in human peripheral monocytes. The production of IL-6 was studied in a glioblastoma cell line, SKMG-4, as well. The trace element preparation BDP significantly stimulated both the constitutive and the endotoxin or IL-1 induced IL-6 production in monocytes or in glial cells, respectively, but revealed no or only modest effect on IL-1 and TNF-α production of monocytes. Moreover, BDP was able to reduce the inhibitory effect of a synthetic corticosteroid, dexamethasone on the biosynthesis of IL-6. The positive effect of the trace element preparation on the IL-6 production of monocytes from rheumatoid arthritis (RA) patients is comparable, to that of on the monocytes from healthy individuals, and similarly to healthy individuals was negligible on the IL-1 and TNF-α production. The detailed analysis of the composition of the preparation suggested, that the major active component in the stimulation of IL-6 production is Zn, but for the complete effect other trace elements are also required.
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Falus, A., Béres, J. A trace element preparation containing zinc increases the production of interleukin-6 in human monocytes and glial cells. Biol Trace Elem Res 51, 293–301 (1996). https://doi.org/10.1007/BF02784084
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DOI: https://doi.org/10.1007/BF02784084