Biological Trace Element Research

, Volume 33, Issue 1–3, pp 37–42 | Cite as

The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism

  • John R. Arthur
  • Fergus Nicol
  • Geoffrey J. Beckett
Article

Abstract

Selenium deficiency impairs thyroid hormone metabolism by inhibiting the synthesis and activity of the iodothyronine deiodinases, which convert thyroxine (T4) to the more metabolically active 3,3′-5 triiodothyronine (T3). Hepatic type I iodothyronine deiodinase, identified in partially purified cell fractions using affinity labeling with [125I]N-bromoacetyl reverse triiodothyronine, is also labeled with75Se by in vivo treatment of rats with75Se-Na2SeO3. Thus, the type I iodothyronine 5′-deiodinase is a selenoenzyme. In rats, concurrent selenium and iodine deficiency produces greater increases in thyroid weight and plasma thyrotrophin than iodine deficiency alone. These results indicate that a concurrent selenium deficiency could be a major determinant of the severity of iodine deficiency.

Index Entries

Selenium deficiency thyroid hormones iodine deficiency effect of dietary selenium iodothyronine deiodinases the role of selenium 

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Copyright information

© Humana Press Inc. 1992

Authors and Affiliations

  • John R. Arthur
    • 1
  • Fergus Nicol
    • 1
  • Geoffrey J. Beckett
    • 2
  1. 1.Division of Biochemical SciencesRowett Research InstituteAberdeenUK
  2. 2.University Department of Clinical ChemistryEdinburghUK

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