Abstract
To examine age-related changes of human cardiac valves, mitral and tricuspid valves were analyzed by inductively coupled plasma-atomic emission spectrometry. The subjects for mitral valves consisted of 12 men and 8 women, ranging in age from 52 to 96 yr. The subjects for tricuspid valves consisted of 11 men and 6 women, ranging in age from 52 to 93 yr. Furthermore, 16 of the samples of the cardiac valves were derived from the same subjects.
The contents of calcium, phosphorus, and magnesium in the mitral valves increased progressively with advancing age and reached maximum in the 80s in regard to calcium and phosphorus and maximum in the 90s in regard to magnesium. The maximum average amounts corresponded to about three times the average contents in the 60s. In contrast, the content of sulfur in the mitral valves remained constant between the 50s and 90s.
Regarding tricuspid valve, the contents of calcium, phosphorus, and magnesium scarcely increased with advancing age, except for one subject who died of chronic renal failure.
Histological observations of the mitral valves revealed that deposits of calcium were present in both the elastic fibers and its degenerative tissues of the mitral valve.
The present study indicates that the accumulation of calcium, phosphorus, and magnesium occurs progressively in the mitral valve with aging, but does not occur in the tricuspid valve.
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Y. Tohno, S. Tohno, T. Minami, M. Ichii, Y. Okazaki, M. Utsumi, et al., Age-related changes of mineral contents in human thoracic aorta and in the cerebral artery,Biol. Trace Element Res. 54, 23–31 (1996).
S. Tohno and Y. Tohno, Age-related differences in calcium accumulation in human arteries,Cell. Mol. Biol. 44, 1253–1263 (1998).
S. Tohno, Y. Tohno, T. Minami, Y. Okazaki, M. Utsumi, F. Nishiwaki et al., A high accumulation of minerals in human internal jugular vein,Biol. Trace Element Res. 62, 17–23 (1998).
Y. Tohno, S. Tohno, M. Utsumi, T. Minami, M. Ichii, Y. Okazaki, et al., Age-indepen- dent constancy of mineral contents in human vertebrae and auditory ossicles,Biol. Trace Element Res. 59, 167–175 (1997).
Y. Tohno, M. Utsumi, S. Tohno, T. Minami, Y. Okazaki, Y. Moriwake, et al., Age- dependent changes of mineral contents in man’s and woman’s calcanei,Biol. Trace Element Res. 60, 81–90 (1997).
Y. Tohno, M. Utsumi, S. Tohno, T. Minami, Y. Okazaki, Y Moriwake, et al., A con- stancy of mineral contents in human auditory ossicles,Acta Anat. Nippon. 72, 531–534 (1997).
S. Tohno, Y. Tohno, T. Minami, M. Ichii, Y Okazaki, M. Utsumi, et al., Difference of mineral contents in human intervertebral disks and its age-related change,Biol. Trace Element Res. 52, 117–124 (1996).
S. Tohno, Y. Tohno, T. Minami, Y Okazaki, M. Utsumi, Y Moriwake, et al., High accu- mulations of calcium and phosphorus in woman’s pubic symphysis,Biol. Trace Ele- ment Res. 59, 177–185 (1997).
Y. Moriwake, Y. Tohno, S. Tohno, T. Minami, M. Utsumi, F. Nishiwaki, et al., Age- related changes of element contents in the human meniscus,Biol. Trace Element Res. 64, 229–235 (1998).
Y. Tohno, Y Moriwake, Y Takano, T. Minami, S. Tohno, M. Utsumi, et al., Age-related changes of element contents in human anterior cruciate ligaments and ligamenta capitum femorum,Biol. Trace Element Res. 68, 181–192 (1999).
M. A. Simon and S. F. Liu, Calcification of the mitral valve annulus and its relation to functional valvular disturbance,Am. Heart J. 48, 497–505 (1954).
A. Pomerance, Pathological and clinical study of calcification of the mitral ring,J. Clin. Pathol. 23, 354–361 (1970).
J. D. Cooksey, B. M. Parker, and C. S. Weldon, Atrial septal defect and calcification of the tricuspid valve,Br. Heart J. 32, 409–411 (1970).
Y. Tohno, S. Tohno, H. Matsumoto, and K. Naito, A trial of introducing soft X-ray apparatus into dissection practice for students (in Japanese),J. Nara Med. Assoc. 36, 365–370 (1985).
W. C. Roberts, J. K. Perloff, and T. Costantino, Severe valvular aortic stenosis in patients over 65 years of age: a clinicopathologic study,Am. J. Cardiol. 27, 497–506 (1971).
B. F. Waller and W. C. Roberts, Cardiovascular disease in the very elderly: analysis of 40 necropsy patients aged 90 years or over,Am. J. Cardiol. 51, 403–421 (1983).
B. S. Epstein, Comparative study of valvular calcifications in rheumatic and in non- rheumatic heart disease,Arch. Intern. Med. 65, 279–290 (1940)
A. Hollman, The anatomical appearance in rheumatic tricuspid valve disease,Br. Heart J. 19, 211–216 (1957).
P. M. Tillotson and I. Steinberg, Roentgen features of rheumatic tricuspid stenosis,Am. J. Roent. Rad. Therapy Nucl. Med. 87, 948–961 (1962).
W. C. Roberts, Morphological features of the normal and abnormal mitral valve (review),Am. J. Cardiol. 51, 1005–1028 (1983).
P. K. Fulkerson, B. M. Beaver, J. C. Auseon, and H. L. Graber, Calcification of the mitral annulus: etiology, clinical association, complications and therapy,Am. J. Med. 66, 967–977 (1979).
D. D. Savage, R. J. Garrison, W. P. Castelli, P. M. McNamara, S. J. Anderson, W. B. Kannel, et al., Prevalence of submitral (anular) calcium and its correlates in a general population-based sample (the Framingham study),Am. J. Cardiol. 51, 1375–1378 (1983).
M. B. Forman, R. Virmani, R. M. Robertson, and W. J. Stone, Mitral anular calcifica- tion in chronic renal failure,Chest 85, 367–371 (1984).
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Tohno, S., Moriwake, Y., Tohno, Y. et al. Age-related changes of element contents in human mitral and tricuspid valves. Biol Trace Elem Res 70, 137–147 (1999). https://doi.org/10.1007/BF02783855
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DOI: https://doi.org/10.1007/BF02783855