Biological Trace Element Research

, Volume 37, Issue 2–3, pp 281–292 | Cite as

Comparison of clastogenic effects of antimony and bismuth as trioxides on mice in vivo

  • Neelam Gurnani
  • Archana Sharma
  • Geeta Talukder


Comparison of the clastogenic effects of antimony and bismuth used as trioxides, when administered orally by gavaging to laboratory bred male mice, showed that the former was more strongly clastogenic than the latter. Three doses of each chemical (400, 666.67, and 1000 mg/kg body wt), corresponding to 1/50, 1/30, and 1/20 of oral LD50 of antimony trioxide, were fed daily to sets of mice up to 21 d. Animals were sacrificed on day 7, 14, and 21 of the experiment. Chromosomal aberrations and mitotic index were studied from bone marrow cells following a colchicine-air drying Giemsa schedule. The frequencies of chromosomal aberrations induced by both chemicals were directly proportional to the dose used and the duration of exposure, indicating their cumulative effects on the organism. The highest dose of antimony, given for the longest period was, however, lethal. Effects on germ cells, as shown by screening for sperm head abnormalities, were not significant.

Index Entries

Antimony trioxide bismuth trioxide clastogenicity chromosomal aberrations 


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Copyright information

© The Humana Press, Inc 1993

Authors and Affiliations

  • Neelam Gurnani
    • 1
    • 2
  • Archana Sharma
    • 1
    • 2
  • Geeta Talukder
    • 1
    • 2
  1. 1.Centre for Advanced Study in Cell and Chromosome Research, Department of BotanyUniversity of CalcuttaCalcutta
  2. 2.Vivekananda Institute of Medical SciencesCalcutta

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