Biological Trace Element Research

, Volume 35, Issue 3, pp 281–297 | Cite as

Effects of excess selenomethionine on selenium status indicators in pregnant long-tailed macaques (Macaca fascicularis)

  • Wayne Chris Hawkes
  • Calvin C. Willhite
  • Kimberly A. Craig
  • Stanley T. Omaye
  • Douglas N. Cox
  • Wai Nang Choy
  • Andrew G. Hendrickx
Article

Abstract

Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold,r=0.958), plasma selenium (22-fold,r=0.885), erythrocyte selenium (24-fold,r=0.920), and fecal selenium (18-fold,r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased 154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8 μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials.

Index Entries

Selenomethionine selenium glutathione peroxidase Macaca fascicularis long-tailed macaque nonhuman primate selenium status assessment selenium toxicity, cancer chemoprevention 

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Copyright information

© The Humana Press, Inc 1992

Authors and Affiliations

  • Wayne Chris Hawkes
    • 1
  • Calvin C. Willhite
    • 2
  • Kimberly A. Craig
    • 3
  • Stanley T. Omaye
    • 5
  • Douglas N. Cox
    • 7
  • Wai Nang Choy
    • 2
  • Andrew G. Hendrickx
    • 9
  1. 1.Western Human Nutrition Research CenterUSDA-ARSPresidio of San Francisco
  2. 2.Department of Health Services, State of CaliforniaBerkeley
  3. 3.Western Human Nutrition Research CenterUSDA-ARSPresidio of San Francisco
  4. 4.Chiron CorporationEmeryville
  5. 5.Letterman Army Institute of ResearchPresidio of San Francisco
  6. 6.Department of NutritionUniversity of NevadaReno
  7. 7.California Public Health FoundationBerkeley
  8. 8.ENVIRON CorporationEmeryville
  9. 9.California Primate Research CenterUniversity of CaliforniaDavis

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