The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism

Abstract

Selenium deficiency impairs thyroid hormone metabolism by inhibiting the synthesis and activity of the iodothyronine deiodinases, which convert thyroxine (T4) to the more metabolically active 3,3′–5 triiodothyronine (T3). Hepatic type I iodothyronine deiodinase, identified in partially purified cell fractions using affinity labeling with [125I]N-bromoacetyl reverse triiodothyronine, is also labeled with75Se by in vivo treatment of rats with75Se−Na2SeO3. Thus, the type I iodothyronine 5′-deiodinase is a selenoenzyme. In rats, concurrent selenium and iodine deficiency produces greater increases in thyroid weight and plasma thyrotrophin than iodine deficiency alone. These results indicate that a concurrent selenium deficiency could be a major determinant of the severity of iodine deficiency.

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References

  1. 1.

    J. L. Leonard and T. J. Visser,Thyroid Hormone Metabolism, Heinneman, G., ed., Marcel Dekker, New York, 1986, pp. 189–229.

    Google Scholar 

  2. 2.

    G. J. Beckett, S. E. Beddows, P. C. Morrice, F. Nicol, and J. R. Arthur,Biochem. J. 248, 443–447 (1987).

    PubMed  CAS  Google Scholar 

  3. 3.

    J. R. Arthur, F. Nicol, R. Boyne, K. G. D. Allen, J. D. Hayes, and G. J. Beckett,Trace Substances in Environmental Health, vol. 21, Hemphill, D. D., ed., University of Missouri, Colombia, 1987, pp. 487–498.

    Google Scholar 

  4. 4.

    R. F. Burk,Ann. Rev. Nutr. 3, 53–70 (1983).

    Article  CAS  Google Scholar 

  5. 5.

    R. F. Burk,J. Nutr. 119, 1051–1054 (1989).

    PubMed  CAS  Google Scholar 

  6. 6.

    R. A. Sunde,Annu. Rev. Nutr. 10, 451–474 (1990).

    PubMed  Article  CAS  Google Scholar 

  7. 7.

    J. R. Arthur, P. C. Morrice, F. Nicol, S. E. Beddows, R. Boyd, J. D. Hayes, and G. J. BeckettBiochem. J. 248, 539–544 (1987).

    PubMed  CAS  Google Scholar 

  8. 8.

    G. J. Beckett, D. A. MacDougall, F. Nicol, and J. R. Arthur,Biochem. J. 259, 887–892 (1989).

    PubMed  CAS  Google Scholar 

  9. 9.

    J. R. Arthur, F. Nicol, A. R. Hutchinson, and G. J. Beckett,J. Inorg. Biochem. 39, 101–108 (1990).

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    J. R. Arthur, F. Nicol, P. W. H. Rae, and G. J. Beckett,Clin Chem. Enzm. Comms. 3, 209–214 (1990).

    Google Scholar 

  11. 11.

    J. R. Arthur F. Nicol, G. J. Beckett, and P. Trayhurn,Can. J. Physiol. Pharmacol. 69, 782–785 (1991).

    PubMed  CAS  Google Scholar 

  12. 12.

    J. R. Arthur, F. Nicol, E. Grant, and G. J. Beckett,Biochem. J. 274, 297–300 (1991).

    PubMed  CAS  Google Scholar 

  13. 13.

    J. R. Arthur, F. Nicol, and G. J. Beckett,Biochem. J. 272, 537–540 (1990).

    PubMed  CAS  Google Scholar 

  14. 14.

    M. J. Berry, L. Banu, and P. R. Larsen,Nature 349, 438–440 (1991).

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    M. Safran, A. P. Farwell, and J. L. Leonard,J. Biol. Chem. 266, 13,477–13,480 (1991).

    CAS  Google Scholar 

  16. 16.

    J. R. Arthur, F. Nicol, P. W. H. Rae, and G. J. Beckett,J. Endoc. (suppl)124 240 (1990).

    Google Scholar 

  17. 17.

    A. Géloën, J. R. Arthur, G. J. Beckett, and P. Trayhurn,Biochem. Soc. Trans. 18, 1269–1270 (1990).

    PubMed  Google Scholar 

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Correspondence to John R. Arthur.

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Arthur, J.R., Nicol, F. & Beckett, G.J. The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. Biol Trace Elem Res 34, 321–325 (1992). https://doi.org/10.1007/BF02783686

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Index Entries

  • Selenium deficiency
  • thyroid hormones
  • iodine deficiency
  • effect of dietary selenium
  • iodothyronine deiodinases
  • the role of selenium