In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged 1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL) (p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum zinc level in patients.
It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment should be initiated with zinc.
This is a preview of subscription content, access via your institution.
Buy single article
Instant access to the full article PDF.
Tax calculation will be finalised during checkout.
F. A. Oski, Iron deficiency in infancy and childhood,N. Engl. J. Med. 329, p. 190 (1993).
M. A. Aukett, Y. A. Parks, P. H. Scott, and B. A. Wharton, Treatment with iron increases weight gain and psychomotor development,Arch. Dis. Child 71, 877–880 (1986).
F. A. Oski, and J. A. Stockman, Anemia due to inadequate iron sources or poor iron utilization,Pediatr. Clin. North Am. 27, 237–252 (1980).
M. H. N. Golden, The nature of nutritional deficiency in relation to growth failure and poverty,Ada. Paediatr. Scand. Suppl. 374, 95–110 (1991).
J. Hastka, J. J. Lasserre, A. Schwarzbeck, and R. Hehlmann, Central role of zinc protoporphyrin in staging iron deficiency,Clin. Chem. 40, 768–773 (1994).
I. J. Newhouse, D. B. Clement, and C. Lai, Effects of iron supplementation and discontinuation on serum copper, zinc, calcium, and magnesium levels in women,Med. Sci. Sports Exerc. 25, 562–571 (1993).
H. K. Brown, C. F. Lanata, M. L. Yuen, J. M. Peerson, B. Butron, and B. Lönnerddal, Potential magnitude of the misclassification of a population’s trace element status due to infection: example from a survey of young Pruvian children,Am. J. Clin. N. 58, 549–554 (1993).
J. A. T. Pennington and H. N. Church, Bowes and Church’s food values of portions commonly used, 14th Ed. Philadelphia, JB Lippincott Co. 1985.
G. A. Leveille, M. E. Zabik, and K. J. Morgan, Nutrients in foods. Cambridge MA. The Nutrition Guild, 1983.
Committee on Dietary Allowances Food and Nutrition Board, National Research Council, Recommended dietary allowances ed. 9, Washington DC, National Academy of Sciences, 1980.
A. S. Prasad, J. A. Helsted, and M. Nadami, Syndrome of iron deficiency anaemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia,Am. J. Med. 31, 532–546 (1961).
A. Prasad, Discovery of human zinc deficiency and studies in an experimental human model,Am. J. Clin. Nutr. 53, 403–412 (1991).
N. W. Solomons, Zinc and copper, In:Modern Nutrition in Health and Disease, M. E. Shihls and V. R. Young, eds., Lea-Fabirger, Philadelphia, Seventh Edition, 1988.
P. A. Walravens and K. M. Hambidge, Growth of infants fed a zinc supplemented formula,Am. J. Clin. Nutr. 29, 1114–1121 (1976).
L. S. Valberg, P. R. Flanagan, and M. J. Chamberlain, Effects of iron, tin and copper on zinc absorption in humans,Am. J. Clin. Nutr. 40, 536–541 (1984).
M. K. Yadrick, M. A. Kenney, and E. A. Winterfeldt, Iron, copper, and zinc status: response to supplementation with zinc or zinc and iron in adult females,Am. J. Clin. Nutr. 49, 145–150 (1989).
E. M. Widdowson, Absorption, excretion and storage of trace elements: studies over 50 years,Food Chem. 43, 203–207 (1992).
M. C. Latham, L. S. Stephenson, and S. N. Kinoti, et al, Improvements in growth following iron supplementation in young Kenyan school children,Nutrition 6, 159–162 (1990).
About this article
Cite this article
Ece, A., Uyamik, B.S., IŞcan, A. et al. Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia. Biol Trace Elem Res 59, 31–39 (1997). https://doi.org/10.1007/BF02783227
- Iron deficiency anemia