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Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia


In order to evaluate serum copper and zinc status in children with iron deficiency anemia (IDA), 60 children with IDA aged 1–14 yr and 64 healthy children as controls aged 1–14 yr were included the study. Serum copper levels were higher in children with IDA (189 ± 49 (Μg/dL) than those of controls (163 ± 37 Μg/dL) (p = 0.001). Serum zinc levels were lower in the patient group (109 ± 59 Μg/dL) than those of control subjects (135 ± 56 Μg/dL) (p = 0.017). In addition, there were statistically significant negative correlations between hematological parameters and serum copper levels in the patient group, but not in controls. No correlation between hematological parameters and serum zinc levels were found in both patient and control groups, except positive correlation between mean corpuscular volume (MCV) and serum zinc level in patients.

It was concluded that at the time of managing children with IDA, zinc deficiency must be borne in mind and if necessary treatment should be initiated with zinc.

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Correspondence to Aydin Ece.

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Ece, A., Uyamik, B.S., IŞcan, A. et al. Increased serum copper and decreased serum zinc levels in children with iron deficiency anemia. Biol Trace Elem Res 59, 31–39 (1997).

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Index Entries

  • Iron deficiency anemia
  • copper
  • zinc