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Reversal of selenium and zinc deficiencies in chronic hemodialysis patients by intravenous sodium selenite and zinc gluconate supplementation

Time-course of glutathione peroxidase repletion and lipid peroxidation decrease

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Abstract

In six chronic dialyzed uremic patients, an intravenous sodium selenite (Se 50 μg during 5 wk and then 100 μg) and zinc gluconate (Zn 5 mg) supplementation was performed during 20 wk at each dialysis session three times weekly. Before supplementation, plasma Se and Zn, plasma and erythrocytes (RBC) antioxidant metalloenzymes glutathione peroxidase (GPX), and superoxide dismutase (SOD) were significantly decreased, whereas lipid peroxidation (as thiobarbituric acid reactants TBARs) was increased. To obtain a significative change in plasma selenium, we had to use an Se dose of 100 μg/dialysis session. Then, treatment-increased plasma Se (from 0.58 ±0.09 to 0.89±0.16 μmol/L) led to a repletion of RBC-GPX (from 29.6±6 to 43±5.8 U/g Hb) and increased plasma GPX levels (from 62±13 to 151±43 U/L). Plasma Zn and RBC-SOD did not vary significantly. The change of TBARs was not observed between wk 1 and 4. They decreased significantly between wk 4 (4.80±0.21μmol/L) and wk 20 (4.16±0.26 μmol/L). We noted a low correlation between TBARs and plasma GPX. A strong correlation was observed between Se and plasma GPX. The reversal of Se deficiencies should reduce oxidative damage observed in these patients.

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Authors and Affiliations

  1. Laboratoire de Biochimie C, Hopital A. Michallon, BP 217X, 38043, Grenoble, France

    Marie J. Richard, Veronique Ducros, Josiane Arnaud, Charles Coudray & Alain Favier

  2. A.G.D.U.C., Hopital A. Michallon, BP 217X, 38043, Grenoble, France

    Michel Rorêt

  3. Laboratoire Aguettant, Lyon, France

    Michèle Fusselier

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  1. Marie J. Richard
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  2. Veronique Ducros
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  3. Michel Rorêt
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  4. Josiane Arnaud
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  5. Charles Coudray
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  6. Michèle Fusselier
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  7. Alain Favier
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Richard, M.J., Ducros, V., Rorêt, M. et al. Reversal of selenium and zinc deficiencies in chronic hemodialysis patients by intravenous sodium selenite and zinc gluconate supplementation. Biol Trace Elem Res 39, 149–159 (1993). https://doi.org/10.1007/BF02783185

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  • DOI: https://doi.org/10.1007/BF02783185

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