Summary
A 63-year-old Japanese woman who was being treated for liver cirrhosis was diagnosed as having hepatocellular carcinoma in the caudate lobe of the liver. Transcatheter hepatic arterial chemoembolization was performed for this lesion, but severe neutropenia occurred. To restore white blood cell (WBC) counts, recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered (250 (μg per day during 10 days, intravenously). Subsequently, WBC counts recovered immediately without side effects. This suggests that rhG-CSF could be useful for the treatment of neutropenia after chemoembolization, even in cirrhotic patients.
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References
Nagata S, Tsuchiya M, Asano S, et al: Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature 1986;319:415–417.
Asano S, Ono M: Human granulocyte colony-stimulating factor: Its biological actions and clinical implication. Acta Hematol Jap 1987; 50:1550–1556.
Bronchud MH, Scarffc JH, Thatcher N, et al: Phase 1/2 study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 1987;56:809–813.
Fukuoka M, Ariyoshi Y, Furuse K, et al: Effect of recombinant human G-CSF (rG-CSF) in patients with non-small cell lung cancer (NSCLC) treated with combination chemotherapy of mitomycin C, Vindesine, and cisplatin (MVP chemotheray). Biotherapy 1990;4: 1038–1044. (in Japanese)
Gabrilove JL, Jakubowski A, Scher H, et al: Effect of granulocyte colony-stimulatng factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J MED 1988;318:1414–1422.
Ohsaka A, Kitagawa S, Sakamoto S, et al: In vivo activation of human neutrophil functions by administration of recombinant human granulocyte colony-stimulating factor in patients with malignant lymphoma. Blood 1989;74:2743–2748.
Ota K, Ariyoshi Y, Fukuoka M, et al: Clinical effect of recombinant human G-CSF on neutropenia induced by the chemotherapy for lung cancer. Jap J Cancer Chemother 1990;17:65–71. (in Japanese)
Tukuda M, Yoshida T, Furukawa S, et al: Clinical effects of recombinant human G-CSF on chemotherapy-induced neutropenia in patients with head and neck cancer. Biotherapy 1990;4:236–243. (in Japanese)
Yamada R, Sato M, Kawabata M, et al: Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology 1983;146: 397–401.
Takayasu K, Shima Y, Muramatsu Y, et al: Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology 1987;162:345–351.
Sasaki Y, Imaoka S, Kasugai H, et al: A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge. Cancer 1987;60:1194–1203.
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Furukawa, H., Hara, T., Hoshino, K. et al. An application of recombinant human granulocyte colony-stimulating factor (rhG-CSF) in a case of hepatocellular carcinoma combined with liver cirrhosis in which leukopenia developed after chemoembolization. Gastroenterol Jpn 26, 779–782 (1991). https://doi.org/10.1007/BF02782868
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DOI: https://doi.org/10.1007/BF02782868