Summary
The expression of aubumin mRNA in human liver samples was investigated in order to understand the molecular mechanism of albumin gene expression in various liver diseases. Albumin mRNA in acute hepatic failure and decompensated liver cirrhosis was reduced significantly compared to normal control liver (P<0.05). Serum albumin concentration is closely correlated with alnumin mRNA content (r=0.895, P<0.01). These data suggest that albunim concentration is mainly regulated at albumin mRNA level in the liver despite the presence of other regulatory mechanisms and that expression of albumin mRNA level is correlated with disease severity. But in several cases there was a discrepancy between albumin mRNA level and severity of liver disease, so further investigation of the regulatory factors of albumin gene expression should be performed.
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This Study was supported in part by a grant from the Ministry of Health and Welfare, Japan.
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Ozaki, I., Motomura, M., Setoguchi, Y. et al. Albumin mRNA expression in human liver diseases and its correlation to serum albumin concentration. Gastroenterol Jpn 26, 472–476 (1991). https://doi.org/10.1007/BF02782816
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DOI: https://doi.org/10.1007/BF02782816