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Beneficial effects of fructose-1,6-diphosphate infusion on liver regeneration after ischemie liver injury

  • Liver, Pancreas, and Biliary Tract
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Summary

The effect of fructose-1,6-diphosphate (FDP) on cellular viability after partial hepatectomy in partial ischemie liver was investigated in rats. The administration of FDP did not increase blood flow in the hepatic tissue; however, it significantly suppressed the elevation of serum liver functions for 24 hours after partial hepatectomy. Levels of DNA synthesis, protein synthesis, and labeling index were significantly higher in the groups administered divided doses of FDP before and after partial hepatic ischemia than in the control group (P< 0.01). Thus, these findings indicate that FDP has cytoprotective and hepatotrophic effects on liver with ischemie injury and that divided dose administration of FDP is more effective than bolus doses in decreasing damage following ischemie and reperfusion injury.

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Authors and Affiliations

  1. Department of Gastroenterological Surgery, Wakayama Medical College, 27 Shichibancho, 640, Wakayama, Japan

    Takehiro Nakai M.D., Hiroshi Tanimura, Katsuyoshi Tabuse, Yugo Nagai, Kazunari Mori & Hideki Yamoto

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  1. Takehiro Nakai M.D.
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  2. Hiroshi Tanimura
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  3. Katsuyoshi Tabuse
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  4. Yugo Nagai
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  5. Kazunari Mori
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  6. Hideki Yamoto
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Nakai, T., Tanimura, H., Tabuse, K. et al. Beneficial effects of fructose-1,6-diphosphate infusion on liver regeneration after ischemie liver injury. Gastroenterol Jpn 26, 611–618 (1991). https://doi.org/10.1007/BF02781677

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  • DOI: https://doi.org/10.1007/BF02781677

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