Abstract
The story of transmissible human spongiform encephalopathy, from its origins to the present time, enjoys the commentary of a cast of characters from Shakespeare's imaginary island inThe Tempest, with a brief visit to the real island of Tasmania for a bird's eye view of the prion, and some concluding thoughts about the current state of research in the netherworlds of molecular biology and physical chemistry.
Similar content being viewed by others
References
Creutzfeldt H. G. (1920)Zeitsch ges Neurol. Psychiat. 57, 1.
Creutzfeldt H. G. (1921) inHistologische und Histopathologische Arbeiten über die Grosshirnrinde (Nissl F. and Alzheimer A., eds.), Gustav Fischer, Jena, pp. 1.
Jakob A. (1921)Zeitschr. ges Neurol. Psychiat. 64, 147.
Jakob A. (1921)Med. Klin. 13, 372.
Jakob A. (1921)Deutsche Zeitschr. Nervenheilk 70, 132.
Masters C. L. and Gajdusek D. C. (1982) inRecent Advances in Neuropathology (Smith W. T. and Cavanagh J. B., eds.), Julius Springer, Edinburgh, p. 139.
Jakob A. (1923) inMonographien aus dem Gesamtgebiete der Neurologie und Psychiatric (Foerster O. and Wilmanns K., eds.), Julius Springer, Berlin, p. 215.
Jakob A. (1923)Monogr. Psychiat. (Berlin) 37, 215.
Gerstmann J. (1928)Weiner Med. Wochenschr. 78, 906.
Gerstmann J., Sträussler E., and Scheinker I. (1936)Zeitschr. Neurol. 154, 736.
Kirschbaum W. R. (1968)Jakob-Creutzfeldt Disease, American Elsevier, New York.
Gajdusek D. C. and Zigas V. (1967)New Engl. J. Med. 257, 974.
Hadlow W. J. (1959)Lancet 2, 289.
Cuillé J. and Chelle P. L. (1936)CR Acad. Sci. (Paris) 203, 1552.
Gajdusek D. C., Gibbs C. J., Jr., and Alpers M. (1966)Nature 209, 794.
Klatzo I., Gajdusek D., and Zigas V. (1959)Lab. Invest. 8, 799.
Gibbs C. J., Jr., Gajdusek D. C., Asher D. M., Alpers M. P., Beck E., Daniel P. M., and Matthews W. B. (1968)Science 161, 388.
Masters C., Gajdusek D., and Gibbs C., Jr. (1981)Brain 104, 559.
Roos R., Gajdusek D. C., and Gibbs C. J., Jr. (1973)Brain 96, 1.
Traub R., Gajdusek D. C., and Gibbs C. J., Jr. (1977) inAging and Dementia (Kinsbourne M. and Smith L., eds.), Spectrum, New York, p. 91.
Brown P. (1988) inNovel Infectious Agents and the Central Nervous System.Ciba Foundation Symposium 135 (Bock G. and Marsh J., eds.), Wiley, Chichester, p. 3.
Brown P., Gibbs C. J., Jr., Rodgers-Johnson P., Asher D. M., Sulima M. P., Bacote A., Goldfarb L. G., and Gajdusek D. C. (1993)Ann. Neurol. 35, 513.
Kimberlin R. H. (1976) inSlow Virus Diseases of Animals and Man, Frontiers of Biology, vol. 44 (Neuberger A. and Tatum E. L., eds.), North Holland, Amsterdam.
Merz P. A., Somerville R. A., Wisniewski H. M., and Iqbal K. (1981)Acta Neuropathol. (Berl.) 54, 63.
Merz P. A., Rohwer R. G., Kascsak R., Wisniewski H. M., Somerville R. A., Gibbs C. J. J., and Gajdusek D. C. (1984)Science 225, 437.
Bolton D. C., McKinley M. P., and Prusiner S. B. (1982)Science 218, 1309.
Oesch B., Westaway D., Wälchli M., McKinley M. P., Kent S. H. B., Aebersold R., Barry R. A., Tempst P., Teplow D. B., Hood L. E., Prusiner S. B., and Weissmann C. (1985)Cell 40, 735.
Alper T., Haig D. A., and Clarke M. C. (1966)Biochem. Biophys. Res. Commun. 22, 278.
Alper T., Cramp W. A., Haig D. A., and Clarke M. C. (1967)Nature 214, 764.
Gibbons R. A. and Hunter G. D. (1967)Nature 215, 1041.
Griffith J. S. (1967)Nature 215, 1043.
Adams D. and Field E. (1968)Lancet ii, 714.
Hunter G., Kimberlin R., and Gibbons R. (1968)J. Theoret. Biol. 20, 355.
Alper T., Haig D. A., and Clarke M. C. (1978)J. Gen. Virol. 41, 503.
Cho H. J. (1980)Interurology 14, 213.
Lewin P. K. (1982)Can. Med. Assoc. J. 127, 471.
German T. and Marsh R. (1983)Prog. Mol. Subcell. Biol. 8, 111.
Prusiner S. B. (1982)Science 216, 136.
Yeadon D. (1992)The Washington Post, Washington DC, October 18, p. E1.
Bolton D. C., Meyer R. K., and Prusiner S. B. (1985)J. Virol. 53, 596.
Stahl N., Borchelt D. R., Hsiao K., and Prusiner S. B. (1987)Cell 51, 229.
Bazan J. F., Fletterick R. J., McKinley M. P., and Prusiner S. B. (1987)Protein Eng. 1, 125.
Turk E., Teplow D. B., Hood L. E., and Prusiner S. B. (1988)Eur. J. Biochem. 176, 21.
Endo T., Groth D., Prusiner S., and Kobata A. (1989)Biochemistry 28, 8380.
Caughey B., Dong A., Bhat K., Ernst D., Hayes S., and Caughey W. (1991)Biochemistry 30, 7672.
Basler K., Oesch B., Scott M., Westaway D., Wälchli M., Groth D. F., McKinley M. P., Prusiner S. B., and Weissmann C. (1986)Cell 46, 417.
Hope J., Morton L. J., Farquhar C. F., Multhaup G., Beyreuther K., and Kimberlin R. H. (1986)EMBO J. 5, 2591.
Meyer R. K., McKinley M. P., Bowman K. A., Braunfeld M. B., Barry R. A., and Prusiner S. B. (1986)Proc. Natl. Acad. Sci. USA 83, 2310.
Bendheim P., Potempska A., Kascsak R., and Bolton D. (1988)J. Infect. Dis.,158, 1198.
Safar J., Ceroni M., Gajdusek D., and Gibbs C. Jr. (1991)J. Infect. Dis. 163, 488.
Gordon W. S. (1966) inReport of Scrapie Seminar (ARS 91-53), Washington, DC, p. 53.
Dickinson A. G., Stamp J. T., Renwick C. C., and Rennie J. C. (1968)J. Comp. Pathol. 78, 313.
Dickinson A. G., Meikle V. M. H., and Fraser H. (1968)J. Comp. Pathol. 78, 293.
Carlson G. A., Kingsbury D. T., Goodman P. A., Coleman S., Marshall S. T., De Armond S., Westaway D., and Prusiner S. B. (1986)Cell 46, 503.
Westaway D., Goodman P., Mirenda C. A., McKinley M. P., Carlson G. A., and Prusiner S. B. (1987)Cell 51, 651.
Hunter N., Hope J., McConnell I., and Dickinson A. G. (1987)J. Gen. Virol. 68, 2711.
Hunter N., Foster J. D., Dickinson A. G., and Hope J. (1989)Vet. Rec. 124, 364.
Lowenstein D., Butler D., Westaway D., McKinley M., De Armond S., and Prusiner S. (1990)Mol. Cell Biol. 10, 1153.
Goldmann W., Hunter N., Martin T., Dawson M., and Hope J. (1991)J. Gen. Virol. 72, 201.
Bruce M. E., McConnell I., Fraser H., and Dickinson A. G. (1991)J. Gen. Virol. 72, 595.
Goldfarb L. G., Brown P., and Gajdusek D. C. (1994)Mol. Neurobiol., this issue.
Kretzschmar H. A., Honold G., Seitelberger F., Feucht M., Wessely P., Mehraein P., and Budka H. (1991)Lancet 337 1160.
Brown P. (1992)Rev. Neurol. (Paris) 148, 317.
Goldfarb L. G., Petersen R. B., Tabaton M., Brown P., LeBlanc A. C., Montagna P., Cortelli P., Julien J., Vital C., Pendelbury W. W., Haltia M., Wills P. R., Hauw J. J., McKeever P. E., Monari L., Schrank B., Swergold G. D., Autilio-Gambetti L., Gajdusek D. C., Lugaresi E., and Gambetti P. (1992)Science 258, 806.
Baker H. F., Poulter M., Crow T. J., Frith C. D., Lofthouse R., Ridley R. M., and Collinge J. (1991)Lancet 337, 1286.
Dlouhy S. F., Hsiao K., Farlow M. R., Foroud T., Conneally P. M., Johnson P., Prusiner S. B., Hodes M. E., and Ghetti B. (1992)Nature Genet. 1, 64.
Doh-Ura K., Kitamoto T., Sakaki Y., and Tateishi J. (1991)Nature 353, 802.
Collinge J., Palmer M. S., and Dryden A. J. (1991)Lancet 337, 1441.
Deslys J. P., Marcé D., and Dormont D. (1994)J. Gen. Virol. 75, 23.
Brown P., Goldfarb L. G., Cervenáková L., McCombie W. R., Rubenstein R., Will R. G., Pocchiari M., Martinez-Lage J. F., Scalici C., Masullo C., Graupera G., Ligan J., and Gajdusek D. C. (1994)Neurology 44, 291.
Taglianni F., Prelli F., Verga L., Giaccone G., Salmona M., Passerini F., Wisniewski T., Ghetti B., Bugiani O., and Frangione B. (1992) inBook of Abstracts, Annual Meeting of the Society for Neuroscience, Society for Neuroscience, Anaheim, CA, October 25–30, pp. 1251.
Gasset M., Baldwin M. A., Lloyd D. H., Gabriel J.-M., Holtzman D. M., Cohen F., Fletterick R., and Prusiner S. B. (1992)Proc. Natl. Acad. Sci. USA 89, 10,940.
Goldfarb L., Brown P., Haltia M., Ghiso J., Frangione B., and Gajdusek D. C. (1993)Proc. Soc. Natl. Acad. Sci. USA 90, 4451.
Forioni G., Angeretti N. Chiesa R., Monzani E., Samona M., Bugiani O., and Tagliavini F. (1993)Nature 362, 543.
Kitamoto T., Yamaguchi K, Doh-ura K, and Tateishi J. (1991)Neurology 41, 306.
Beisson J., and Sonneborn T. M. (1965)Proc. Natl. Acad. Sci. USA 53, 275.
Scott M., Foster D., Mirenda C., Serban D, Coufal F., Wälchi M., Torchia M., Groth D., Carlson G., DeArmond S. J., Westaway D., and Prusiner S. B. (1989)Cell 59, 847.
Prusiner S. B., Scott M., Foster D., Pan K.-M., Groth D., Mirenda C., Torchia M., Yang S.-L., Serban D., Carlson G. A., Hoppe P. C., Westaway D., and DeArmond S. J. (1990)Cell 63, 673.
Hsiao K. K., Scott M., Foster D., Groth D. F., DeArmond S. J., and Prusiner S. B. (1990)Science 250, 1587.
Büeler H., Fischer M., Lang Y., Bluethmann H., Lipp H.-P., DeArmond S.-J., Prusiner S. B., Aguet M., and Weissmann C. (1992)Nature 356, 577.
Shlichta P. L. (1991)Brain Res. Rev. 16, 105.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Brown, P. The “brave new world” of transmissible spongiform encephalopathy (infectious cerebral amyloidosis). Mol Neurobiol 8, 79–87 (1994). https://doi.org/10.1007/BF02780657
Issue Date:
DOI: https://doi.org/10.1007/BF02780657