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Measurement of calcium content of gallstones by computed tomography and the relationship between gallbladder function and calcification of gallstones

  • Liver, Pancreas, and Biliary Tract
  • Published:
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Summary

To evaluate the relationship between gallbladder function and calcification of gallstones, we studied gallbladder contractility by oral cholecystography, the computed tomography (CT) number of stones for 30 gallstone patients, calcium content of 13 stones operatively extirpated, and the degree of inflammatory change in 13 surgical gallbladder specimens. There was significant correlation between the calcium content and CT numbers of stones, and 1% of the calcium content of gallstone was approximately equal to 40 Hounsfield Units (HU) of the CT number. The calcium content of stones in patients with normal gallbladder contractility was extrapolated to be below 1.5%, while that with poor contractility ranged from 0% to 21%. Additionally there is a possibility that calcium content increases, related to the inflammatory change of gallbladder. Hence our results suggested that measurement of the CT number of stones is useful to evaluate the calcium content of gallstones, and that the gallbladder contractility could be one of the factors to influence calcification of stones.

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References

  1. Bartum RJ, Crow HC, Foote SR:Ultrasonic and radiographic cholecystography. N Engl J Med1977;296:538–541

    Article  Google Scholar 

  2. Parulekar SG:Ultrasonic detection of calcification in gallstones: the reverberation shadow. J Ultrasound Med1984:3:123–129

    PubMed  CAS  Google Scholar 

  3. Korobkin M, Goldburg H: Gastrointestinal disease, Pathology, Diagnosis, Management: Computerized tomography of the abdomen. W.B. Saunders Co, Philadelphia 1978

    Google Scholar 

  4. Danzinger RG, Hofmann AF, Schoenfield LJ: Dissolution of cholesterol gallstones by chenodeoxycholic acid. N Engl J Med 1972:286:1–8

    PubMed  CAS  Google Scholar 

  5. Nakagawa S, Makino I, Ishizaki T: Dissolution of cholesterol gallstones by ursodcoxycholic acid. Lancer 1977:2:367–369

    Article  CAS  Google Scholar 

  6. Freilich HS, Malet PF, Schwartz JS, et al: Chemical and morphologic characteristics of cholesterol gallstones that failed to dissolve on chenodiol: The National Cooperative Gallstone Study. Gastroenterology 1986:91:713–718

    PubMed  CAS  Google Scholar 

  7. Connerty HV, Briggs AR: Determination of serum calcium by means of orthocrcsolphthalein complexone. Am J Clin Path 1986:45:290–296

    Google Scholar 

  8. Yarnagata S, Maki T, Ohsuga T: New classification of gallstone in Japan. Jpn J Gastroenterol 1986:83:309–316

    Google Scholar 

  9. Onuki K: New attempts using computed tomography in determining indication of galsltone dissolution therapy. Acta Medica et Biologica 1987:34:139–151

    Google Scholar 

  10. Whiting M, Jarvinen V, Watts JM: Chemical composition of gallstones resistant to dissolution therapy with chenodeoxycholic acid. Gut 1980:16:1077–1081

    Article  Google Scholar 

  11. Raedsh R, Stiehl A, Czygan P: Ursodeoxycholic acid and gallstone calcification. Lancet 1981:2:1296

    Article  Google Scholar 

  12. Hickman MS, Schwesinger WH, Bova JD: Computed tomographic analysis of gallstones: an in vitro study. Arch Surg 1986:21:289–291

    Google Scholar 

  13. Moore EW, Celic L, Ostrow D: Interactions between ionized calcium and sodium taurocholate: bile salts are important buffers for prevention of calcium-containing gallstones. Gastrocnterology 1982:83:1079–1089

    CAS  Google Scholar 

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Yoneda, M., Tamasawa, N., Makino, I. et al. Measurement of calcium content of gallstones by computed tomography and the relationship between gallbladder function and calcification of gallstones. Gastroenterol Jpn 25, 478–484 (1990). https://doi.org/10.1007/BF02779337

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  • DOI: https://doi.org/10.1007/BF02779337

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