Summary
A patient with pleomorphic giant cell carcinoma of the gallbladder also had mild neutrophilia, and this tumor was found to be human granulocyte colony-stimulating factor (G-CSF)-positive on immunohistochemical staining. CSF activity in urine and serum was not examined, but leukocytosis disappeared immediately after cholecystectomy. These findings suggest that this was a G-CSF-producing tumor.
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Takeda, T., Ichiyanagi, A., Sano, K. et al. A case of gallbladder cancer producing granulocyte-colony-stimulating factor. Gastroenterol Jpn 25, 762–767 (1990). https://doi.org/10.1007/BF02779193
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DOI: https://doi.org/10.1007/BF02779193