Summary
In order to know the mechanisms responsible for producing the difference in basal secretion between gastric and duodenal ulcer, secretory response of the stomach to gastric secretory depressants of differenent acting mechanisms was compared. The intravenous administration of an anticholinergic agent “glycopyrrolate” reduced both basal acid and pepsin output more profoundly in duodenal ulcer than gastric ulcer, while intravenous administration of secretin yielded the opposite results in acid secretion in contrast to the indifinite tendency observed in pepsin secretion. In this connection secretin was shown to depress the gastrin-mediated acid secretion of the stomach. It was concluded that the elevated basal secretion in duodenal ulcer is caused under the more intensive vagal influence than gastric ulcer, and basal acid secretion in gastric ulcer is relatively under the intensive influence of gastrin-mediated humoral secretory mechanism in comparison with duodenal ulcer. Key words : peptic ulcer, gastric ulcer, duodenal ulcer, gsatric secretion, acid, pepsin, gastrin, gastric secretory depressant, anticholinergic agent, glycopyrrolate, secretory cell mass, neural secretory mechanism, humoral secretory mechanism, secretin.
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Ishimori, A., Yamagata, S., Miura, Y. et al. Difference in secretory response of the stomach to various gastric secretory depressants between gastric and duodenal ulcer. Gastroenterol Jpn 8, 353–362 (1973). https://doi.org/10.1007/BF02779112
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DOI: https://doi.org/10.1007/BF02779112