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RNA virus evolution, population dynamics, and nutritional status

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Abstract

Trace elements exert a strong influence on immune function. Debilitated humoral and cellular immune responses may impair virus clearance in infected organisms, and favor the generation of virus variants with altered biological properties. The population size in evolving viral quasispecies, as well as increased mutagenesis trigered by oxidative stress, may contribute to altering the outcome of quasispecies evolution in infected hosts. The genetic plasticity of RNA viruses is one of the main obstacles for the control of the diseases they cause and probably a major force in the emergence of new viral pathogens. Recent results suggest links between nutritional deficiencies and the generation of variant viruses, a possibility that is addressed in the present article.

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  1. Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, 28049, Madrid, Spain

    Esteban Domingo

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  1. Esteban Domingo
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Correspondence to Esteban Domingo.

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Domingo, E. RNA virus evolution, population dynamics, and nutritional status. Biol Trace Elem Res 56, 23–30 (1997). https://doi.org/10.1007/BF02778981

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