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Influence of silver, mercury, lead, cadmium, and selenium on glutathione peroxidase and transferase activities in rats

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Abstract

At the levels used in the experiments, mercury and silver significantly depressed the activity of glutathione peroxidase (assayed with either H2O2 or cumene-OOH) in rat tissues, whereas cadmium or lead had no effect on this activity. The most pronounced effects of mercury and silver on glutathione peroxidase were found in the liver and kidneys, with much less effect in the testes and erythrocytes. Similar trends for the effects of these metals were noted for tissue selenium levels. Silver and mercury significantly depressed the selenium concentrations, but cadmium and lead had no effect upon the selenium levels. Mercury and silver had no effect upon the activity of glutathione transferase in liver and testes, but mercury caused a significant initial increase of its activity in the kidneys. At no time did silver have any significant effect on its activity in this organ.

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References

  1. S. L. Shaver and K. E. Mason,Anat. Rec. 109, 382 (1951).

    Google Scholar 

  2. A. T. Diplock, J. Green, J. Bunyan, D. McHale, and I. R. Muthy,Brit. J. Nutr. 21, 115 (1967).

    Article  PubMed  CAS  Google Scholar 

  3. J. Bunyan, A. T. Diplock, M. A. Cawthorne, and J. Green,Brit. J. Nutr. 22, 165 (1968).

    Article  PubMed  CAS  Google Scholar 

  4. P. Grasso, R. Abrahan, R. Hendy, A. T. Diplock, L. Goldberg, and J. Green,Exp. Mol. Pathol. 11, 186 (1969).

    Article  PubMed  CAS  Google Scholar 

  5. P. D. Whanger, “Selenium Versus Metal Toxicity in Animals,” inProceedings of the Symposium on Selenium-Tellurium in the Environment, Industrial Health Foundation, Pittsburgh, PA, 1976, p. 234.

  6. P. D. Whanger and P. H. Weswig,Nutr. Reports Intern. 8, 421 (1978).

    Google Scholar 

  7. P. A. Wagner, W. G. Hoekstra, and H. E. Ganther,Proc. Soc. Exptl. Biol. Med. 148, 1106 (1975).

    CAS  Google Scholar 

  8. K. E. M. McCoy and P. H. Weswig,J. Nutr. 98, 383 (1969).

    PubMed  CAS  Google Scholar 

  9. D. E. Paglia and W. N. Valentine,J. Lab. Clin. Med. 70, 158 (1967).

    PubMed  CAS  Google Scholar 

  10. P. D. Whanger, P. H. Weswig, J. A. Schmitz, and J. E. Oldfield,J. Nutr. 107, 1298 (1977).

    PubMed  CAS  Google Scholar 

  11. R. S. Black, M. J. Tripp, P. D. Whanger, and P. H. Weswig,Bioinorg. Chem. 8, 161 (1978).

    Article  PubMed  CAS  Google Scholar 

  12. W. H. Habig, M. J. Pabst, and W. G. Jakoby,J. Biol. Chem. 249, 7130 (1974).

    PubMed  CAS  Google Scholar 

  13. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall,J. Biol. Chem. 193, 265 (1951).

    PubMed  CAS  Google Scholar 

  14. O. E. Olson,J. Assoc. Office. Anal. Chem. 52, 627 (1969).

    CAS  Google Scholar 

  15. P. D. Whanger, P. H. Weswig, J. A. Schmitz, and J. E. Oldfield,J. Nutr. 107, 1288 (1977).

    PubMed  CAS  Google Scholar 

  16. O. Wada, N. Yamaguchi, T. Ono, M. Nagahashi, and T. Morimura,Environ. Res. 12, 75 (1976).

    Article  CAS  Google Scholar 

  17. J. R. Prohaska, M. Mowafy, and H. E. Ganther,Chem. Biol. Intern. 18, 253 (1977).

    Article  CAS  Google Scholar 

  18. C. Little and P. J. O’Brien,Biochem. Biophys. Res. Commun. 31, 145 (1968).

    Article  PubMed  CAS  Google Scholar 

  19. S. T. Omaye and A. L. Tappel,Res. Comm. Chem. Path. Pharm. 12, 695 (1975).

    CAS  Google Scholar 

  20. A. T. Diplock,CRC Crit. Rev. Toxic. 4, 271 (1976).

    CAS  Google Scholar 

  21. R. A. Lawrence and R. F. Burk,Biochem. Biophys. Res. Comm. 71, 952 (1976).

    Article  PubMed  CAS  Google Scholar 

  22. P. D. Whanger, M. J. Tripp, R. S. Black, and P. H. Weswig, inTEMA-III Proceedings, M. Kirchgessner, ed., 1978, p. 85.

  23. J. R. Prohaska and H. E. Ganther,Biochem. Biophys. Res. Comm. 76, 437 (1977).

    Article  CAS  Google Scholar 

  24. S. H. Oh, A. L. Pope, and W. G. Hoekstra,J. Anim. Sci. 42, 984 (1976).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Agricultural Chemistry, Oregon State University, 97331, Corvallis, Oregon

    R. S. Black, P. D. Whanger & M. J. Tripp

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  1. R. S. Black
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  2. P. D. Whanger
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  3. M. J. Tripp
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Black, R.S., Whanger, P.D. & Tripp, M.J. Influence of silver, mercury, lead, cadmium, and selenium on glutathione peroxidase and transferase activities in rats. Biol Trace Elem Res 1, 313–324 (1979). https://doi.org/10.1007/BF02778833

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  • DOI: https://doi.org/10.1007/BF02778833

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