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Effect of cadmium on antioxidant status in alloxane-induced diabetic rats

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Abstract

Fifty-two healthy Swiss Male Albino rats aged two mo were used in this study. They were divided into four groups: control (C), diabetic (D), cadmium (Cd), and diabetic+Cd (D+Cd) groups. Diabetic condition was induced in D and D+Cd groups by administration of alloxane (5 mg/100 g). After this treatment, CD and D+Cd groups were injected with CdCl2 ip (2 mg/kg/wk). At the end of the 2-mo experimental period, thiobarbituric acid reactive substances (TBARS), plasma and erythrocyte selenium (SE), plasma ceruloplasmin (Cp), and vitamin E (vit E) were determined in four groups of rats.

The erythrocyte Se was lower in the experimental groups than in the controls. Plasma Se was significantly decreased in the D and D+Cd groups compared with the control group. Plasma Cp was unaltered. Plasma vit E was significantly decreased in Cd group in comparison with the C, D, and D+Cd groups.

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Authors and Affiliations

  1. Department of Biochemistry, Akdeniz University, Faculty of Medicine, Arapsuyu-Antalya, Turkey

    Saadet Gümüşlü & Yakup Alicigüzel

  2. Department of Biophysics, Akdeniz University, Faculty of Medicine, Arapsuyu-Antaluya, Turkey

    Piraye Yargiçoğlu

  3. Department of Physiology, Akdeniz University, Faculty of Medicine, Arapsuyu-Antalya, Turkey

    Aysel Ağar & Mustafa Edremitlioğlu

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Gümüşlü, S., Yargiçoğlu, P., Ağar, A. et al. Effect of cadmium on antioxidant status in alloxane-induced diabetic rats. Biol Trace Elem Res 57, 105–114 (1997). https://doi.org/10.1007/BF02778193

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