Summary
A rare case of primary biliary cirrhosis, ulcerative colitis and chronic myelocytic leukemia is described in a 49-year-old Japanese diabetic woman. Primary biliary cirrhosis was diagnosed by characteristic liver histology and positive serum mitochondrial antibody test. Ulcerative colitis was diagnosed by typical findings of barium enema and colonoscopy, negative fecal test for pathogens and compatible rectal histology. Chronic myelocytic leukemia was determined by representative hematologic findings and positive result for Ph1 chromosome. This is the first case with combination of primary biliary cirrhosis, ulcerative colitis and chronic myelocytic leukemia.
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References
Lupinetti M, Mehigan D, Cameron JL: Hepatobiliary complications of ulcerative colitis. Am J Surg 1980;139:113–118.
Weisner RH, La Russo NF: Clinicopathological features of the syndrome of primary sclerosing cholangitis. Gastroenterology 1980;79:200–296.
Kato Y, Morimoto H, Unoura M, et al: Primary biliary cirrhosis and chronic pancreatitis in a patient with ulcerative colitis. J Clin Gastroenterol 1985;7:425–427.
Bush A, Mitchson H, Walt R, et al: Primary biliary cirrhosis and ulcerative colitis. Gastroenterology 1987;92:2009–2013.
Miyachi K, Watanabe S, Yamashiki T, et al: Precipitating antimitochondrial antibodies in Japanese patients with primary biliary cirrhosis. Am J Gastroenterol 1984;79:704–709.
Shepherd HA, Silby WS, Chapman RWG, et al: Ulcerative colitis and persistent liver dysfunction. Quart J Med 1983;208:503–513.
Warren KW, Athanassiales S, Monge JI, et al: Primary sclerosing cholangitis. Am J Surg 1966;111:23–28.
Carey JB: Bile acids, cirrhosis and human evolution. Gastroenterology 1964;46:490–492.
Chapman RW, Cottone M, Selby W, et al: Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis. Gut 1985;27:86–91.
Fabry TL, Sachar DB, Janowitz HD: Acute myelogenous leukemia in patients with ulcerative colitis. J Clin Gastroenterol 1980;2:225–227.
Cuttner J: Increased incidence of acute promyelocytic leukemia in patients with ulcerative colitis. Ann Intern Med 1982;97:864–865.
Hanauer SB, Wrong KK, Frank PH, et al: Acute leukemia following inflammatory bowel disease. Dig Dis Sci 1982;27:545–548.
Cohn EM, Pearlstine B: Inflammatory bowel disease and leukemia. J Clin Gastroenterol 1984;6:33–35.
Madjlessi SHM, Farmer RG, Weick JK: Inflammatory, bowel disease and leukemia. Dig Dis Sci 1986;31:1025–1031.
Greenstein AJ, Gennuso R, Sachar DB, et al: Extraintestinal cancers in inflammatory bowel disease. Cancer 1985;56:2914–2921.
Madjlessi SHM, Farmer RG, Easley KA, et al: Colorectal and extracolonic malignancy in ulcerative colitis. Cancer 1986;58:1569–1574.
Triantafillidis JK, Tsamakides K, Bourboulis N, et al: Acute leukemia following ulcerative colitis. Am J Gastroenterol 1987;82:1334–1336.
Herberman RB, Holden HT. Natural cell mediated immunity. Adv Cancer Res 1978;27:305–377.
Santoli D, Koprowski H. Mechanisms of activation of human natural killer cells against tumor and virusinfected cells. Immunol Rev 1979;44:125–163.
Vierling JM, Nelson DL, Strober W, et al: In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis: dys-function of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis. J Clin Invest 1977;60:1116–1128.
Ginsberg CH, Dambrauskas JT, Ault KA, et al: Impaired natural killer cell activity in patients with inflammatory bowel disease: evidence for a qualitative defect. Gastroenterology 1983;85:846–851.
Kawase T, Kusugami K, Matsunaga H, et al: Impaired regulation of natural killer cells in immunoglobulin synthesis by peripheral blood mononuclear cells from patients with ulcerative colitis. Gastroenterol Jpn 1990;25:585–592.
Rajaram N, Tatake RJ, Advani SH, et al: Natural killer and lymphokine-activated killer cell functions in chronic myeloid leukemia. Cancer Immunol Immunother 1990;31:44–48.
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Akahoshi, K., Miyata, Y., Hashimoto, M. et al. A case of combined primary biliary cirrhosis, ulcerative colitis and chronic myelocytic leukemia. Gastroenterol Jpn 27, 252–257 (1992). https://doi.org/10.1007/BF02777731
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DOI: https://doi.org/10.1007/BF02777731