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Soluble HLA Class I antigens in sera of patients with chronic hepatitis

  • Liver, Pancreas, and Biliary Tract
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Summary

Soluble HLA Class I antigens in sera (serum-HLA Class I, s-HLA Class I) of patients with chronic hepatitis (CH) were measured with an enzyme-linked double determinant immunoassay (EDDIA). The mean titers of s-HLA Class I antigens of patients with CPH (mean±standard deviation, 2.22±1.60), CAH2A (2.24±1.65) or CAH2B (2.73±1.46) were significantly higher than that of normal subjects (0.36±0.27) (P< 0.01). The titer of s-HLA Class I correlated significantly with the level of serum glutamic pyruvic transaminase (s-GPT) (r=0.73), and weakly with serum level of β2-microglobulin (r=0.43). In patients with chronic hepatitis type B (CH-B) treated with human lymphoblastoid interferon alpha (IFNα), the titer of s-HLA Class I antigens increased. The increased level of s-HLA Class I antigens in the clinical course of chronic hepatitis may be caused by their release from necrotizing hepatocytes which have acquired the expression of HLA Class I antigens on the cell-surface membrane during viral infection.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, 700, Okayama, Japan

    Kohsaku Sakaguchi M.D., Norio Koide, Tatsurou Takenami, Hiroshi Matsushima, Hiroyuki Takabatake & Takao Tsuji

  2. Department of Microbiology & Immunology, New York Medical College, Valhalla, NY, USA

    Soldano Ferrone

Authors
  1. Kohsaku Sakaguchi M.D.
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  2. Norio Koide
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  3. Tatsurou Takenami
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  4. Hiroshi Matsushima
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  5. Hiroyuki Takabatake
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  6. Soldano Ferrone
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  7. Takao Tsuji
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Sakaguchi, K., Koide, N., Takenami, T. et al. Soluble HLA Class I antigens in sera of patients with chronic hepatitis. Gastroenterol Jpn 27, 206–211 (1992). https://doi.org/10.1007/BF02777724

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  • DOI: https://doi.org/10.1007/BF02777724

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