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Immunohistochemical analysis of gastrointestinal carcinoids

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Summary

Clinicopathological and immunohistochemical analyses were performed on ten samples of gastrointestinal carcinoids resected in Ishikawa Prefectural Central Hospital. All samples showed positive reaction to chromogranin A. Serotonin was detected in 8 samples, somatostatin in 4 samples, gastrin in 2 samples. Glucagon/Glicentin in 1 sample, and PYY production in 2 samples. CEA production was detected in 8 samples, and microvascular invasion was observed in 6 of these 8 patients. The PCNA/cyclin labeling index (L.I.) of the cases with metastases was significantly higher than those without metastases. In conclusion, the expression of CEA and the PCNA/cyclin L.I. may be useful markers of the malignant potential of carcinoid tumors.

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Authors and Affiliations

  1. Department of Surgery, Ishikawa Prefectural Central Hospital, 153 Minamishinbo-machi, 920-02, Kanazawa City, Ishikawa, Japan

    Hiroyuki Hayashi M.D., Masaaki Nakagawa, Susumu Kitagawa, Tetsuji Yamada & Kazuki Ishida

  2. Department of Pathology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan

    Hiroshi Kurumaya

Authors
  1. Hiroyuki Hayashi M.D.
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  2. Masaaki Nakagawa
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  3. Susumu Kitagawa
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  4. Tetsuji Yamada
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  5. Kazuki Ishida
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  6. Hiroshi Kurumaya
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Hayashi, H., Nakagawa, M., Kitagawa, S. et al. Immunohistochemical analysis of gastrointestinal carcinoids. Gastroenterol Jpn 28, 483–490 (1993). https://doi.org/10.1007/BF02776945

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  • DOI: https://doi.org/10.1007/BF02776945

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