Summary
Secretory responses to subcutaneously or intravenously administered betazole hydrochloride of graded doses were compared between acid and pepsin in the dog with gastric fistula. Although the dose related increments in acid and pepsin outputs were parallel in the range of lower doses than 2.0 to 3.0 mg/kg body weight of betazole hydrochloride, higher doses caused in decrease in pepsin output, but did not in acid output. It was pointed out that the dose of betazole hydrochloride that stimulates acid secretion maximally dose not correspond to the maximal stimulation for pepsin secretion in the dog.
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Long, J.F. and Brooks, F.P.: The comparative gastric acid and pepsin response to histamine, insulin hypoglycemia and feeding in dogs with vagally innervated gastric pouches. Quart. J. Exp. Physiol. 50: 256–262, 1965.
Aubrey, D.A.: The effects on human gastric secretion of prolonged continuous intravenous infusions of maximal and supramaximal doses of histamine acid phosphate and pentagastrin. Gut 11: 392–394, 1970.
Merritt, A.M. and Brooks, F.P.: Basal and histamine-induced gastric acid and pepsin secretion in the conscious miniature pig. Gastroenterology 58: 801 814, 1970.
Mignon, M., Varro, V., Vatier, J. and Bonfils, S.: 2 DDG stimulation of gastric acid and pepsin secretion in dogs. Acta Hepato-Gastroenterol. 19: 464–469, 1972.
Wilson, R.Y., Dymock, I.W. and Cowley, D.J.: Acid and pepsin dose-response studies to insulin hypoglycaemia in a healthy man. Digestion 11: 90–97, 1974.
Passaro, E.P., Jr. and Grossman, M.I.: Effect of vagal innervation on acid and pepsin response to histamine and gastrin. Am. J. Physiol. 206: 1068–1076, 1964.
Desai, H.G., Zaveri, M.P. and Antia, F.P.: Comparison of dose response curves with subcutaneous and intravenous histamine. Gastroenterology 59: 701–706, 1970.
Dutt, B. and Magee, D.F.: Pepsin secretion by Heidenhain pouches in dogs. Amer. J. Physiol. 223: 480–483, 1972.
Schofield, B.: The inhitition of pepsin output in separated gastric pouches in dogs following feeding and its correlation with motility changes. Gastroenterology 37: 169–180, 1959.
Ishimori, A., Sakurada, H. and Yamagata, S.: Gastrectomy and secretory function of the stomach. Tohoku J. Exp. Med. 107: 1–13, 1972.
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Ishimori, A., Sakurada, H., Kawamura, T. et al. Comparison of dose-response curves between acid and pepsin to betazole hydrochloride in the dog with gastric fistula. Gastroenterol Jpn 10, 221–224 (1975). https://doi.org/10.1007/BF02776656
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DOI: https://doi.org/10.1007/BF02776656