Skip to main content

Regulation of interdigestive contractions in the denervated stomach

Gastroenterologia Japonica volume 18, pages 417–427 (1983)Cite this article

Summary

The effects of thiopental sodium on the regulation of interdigestive migrating contractions (IMC) in the stomach were investigated in dogs with extrinsically denervated fundic pouches.

During the interdigestive state, strong phasic contractions in the pouch took place consistently in accordance with the IMC in the main stomach. The cyclic increase in plasma motilin concentration was more closely correlated with the increase in contractile activity in the pouch than the increase in the main stomach. General anesthesia by thiopental sodium promptly inhibited the IMC in the main stomach but the contractile activity in the pouch was not affected but gradually decreased in proportion to the decrease in plasma motilin concentration.

In conclusion, contractile activity in the extrinsically denervated pouch, which is quite independent of the CNS, is directly controlled by a humoral factor(s), motilin. However, interdigestive motor activity in the extrinsically intact stomach appears to be regulated by the CNS as well as peripheral circulation humoral factors.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. Itoh Z, et al: Changes in plasma motilin concentration and gastrointestinal contractile activity in conscious dogs. Am J Dig Dis 23: 929–935, 1978

    PubMed  Article  CAS  Google Scholar 

  2. Lee KY, et al: Radioimmunoassay of motilin. Validation and studies on the relationship between plasma motilin and interdigestive myoelectric activity of the duodenum of dog. Am J Dig Dis 23: 789–795, 1978

    PubMed  Article  CAS  Google Scholar 

  3. Marik F, et al: Control of the interdigestive myoelectric activity in dogs by the vagus nerves and pentagastrin. Gastroenterology 69: 387–395, 1975

    PubMed  CAS  Google Scholar 

  4. Miolan J-P, et al: Discharge of efferent vagal fibers supplying gastric antrum: indirect study by nerve suture technique. Am J Physiol 235 (Endocrinol Metab Gastrointest Physiol 4): E366-E373, 1978

    PubMed  CAS  Google Scholar 

  5. Ormsbee HS III, et al: The role of the cholinergic nervous system in the gastrointestinal response to motilin in vivo. In Gastrointestinal Motility in Health and Disease, HL Duthie (ed). Lancaster, MTP Press, 1978, pp 113–122

    Google Scholar 

  6. Itoh Z, et al: Hunger contractions and motilin. In Proceedings of the 5th International Symposium on Gastrointestinal Motility, G Vantrappen (ed). Herentals, Belgium, Typoff-Press, 1975, pp 48–55

    Google Scholar 

  7. Itoh Z, et al: Motilin-induced mechanical activity in the alimentary tract. Scand J Gastroent 11, Suppl 39: 93–110, 1976

    CAS  Google Scholar 

  8. Wingate DL, et al: Motilin-induced electrical activity in the canine gastrointestinal tract. Scand J Gastroent 11, Suppl 39: 111–118, 1976

    CAS  Google Scholar 

  9. Bueno L, et al: Effects of anesthesia and surgical procedures on intestinal myoelectric activity in rats. Am J Dig Dis 23: 690–695, 1978

    PubMed  Article  CAS  Google Scholar 

  10. Bueno L, et al: Postoperative intestinal motility in dogs and sheep. Am J Dig Dis 23: 682–689, 1978

    PubMed  Article  CAS  Google Scholar 

  11. Itoh Z, et al: Neural regulation of inter-digestive motor activity in canine jejunum. Am J Physiol 240 (Gastrointest Liver Physiol 3): G324–330, 1981

    PubMed  CAS  Google Scholar 

  12. Itoh Z, et al: An extraluminal force transducer for recording contractile activity of the gastrointestinal smooth muscle in the conscious dogs: Its construction and implantation. Gastroenterol Jpn 12: 275–283, 1977

    PubMed  CAS  Google Scholar 

  13. Itoh Z, et al: Diurnal changes in gastric motor activity in conscious dogs. Am J Dig Dis 22: 117–124, 1977

    PubMed  Article  CAS  Google Scholar 

  14. Thomas PA, et al: Hormonal control of interdigestive motor cycles of canine proximal stomach. Am J Physiol 237 (Endocrinol Metab Gastrointest Physiol 6): E192-E197, 1979

    Google Scholar 

  15. Itoh Z, et al: Interdigestive motor activity of heidenhain pouches in relation to main stomach in conscious dogs. Am J Physiol 234 (Endocrinol Metab Gastrointest Physiol 3): E333-E338, 1978

    PubMed  CAS  Google Scholar 

  16. Farrell JI, et al: Studies on the motility of the transplanted gastric pouch. Am J Physiol 76: 227–228, 1926

    Google Scholar 

  17. Bercovitz Z: Studies of the motility of the denervated Heidenhain pouch. Am J Physiol 72: 109–118, 1925

    Google Scholar 

  18. Thomas PA, et al: Does motilin regulate canine interdigestive gastric motility? Dig Dis Sci 24: 577–582, 1979

    PubMed  Article  CAS  Google Scholar 

  19. Chey WY, et al: Endogenous plasma motilin concentration and interdigestive myoelectric activity of the canine duodenum. In Gut Hormones, SR Bloom (ed.) Edinburgh, London & New York, Churchill Livingstone, 1978, pp 355–358

    Google Scholar 

  20. Harvey SC: In The Pharmacological Basis of Therapeutics, Gilman AG, Goodman LS, Gilman A (eds.) New York, Macmillan Publishing Co, 1980, pp 352–355

    Google Scholar 

  21. Jessen KR, et al: γ-Aminobutyric acid may be a neurotransmitter in the vertebrate peripheral nervous system. Nature (London) 281: 71–74, 1979

    Article  CAS  Google Scholar 

  22. Marlett JA, et al: Effect of celiac and superior mesenteric ganglionectomy on interdigestive myoelectric complex in dogs. Am J Physiol 237: E432–436, 1979

    PubMed  CAS  Google Scholar 

  23. Lerman SH, et al: Pyloric motor response to sympathetic nerve stimulation in dogs. Surgery 89: 460–465, 1981

    PubMed  CAS  Google Scholar 

Download references

Author information

Affiliations

  1. Gastrointestinal Laboratories, Department of Surgery, Gunma University School of Medicine, Maebashi, Japan

    Mitsuo Nakaya M.D., Itsuo Takahashi M.D., Tomoaki Suzuki M.D., Shinjin Takeuchi M.D., Hisako Arai M.S., Katsumi Wakabayashi Ph.D. & Zen Ito M.D., Ph.D.

Authors
  1. Mitsuo Nakaya M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Itsuo Takahashi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomoaki Suzuki M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shinjin Takeuchi M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hisako Arai M.S.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Katsumi Wakabayashi Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zen Ito M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Nakaya, M., Takahashi, I., Suzuki, T. et al. Regulation of interdigestive contractions in the denervated stomach. Gastroenterol Jpn 18, 417–427 (1983). https://doi.org/10.1007/BF02776580

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02776580

Key Words

  • barbiturate
  • extrinsically denervated fundic pouch
  • force transducer
  • general anesthesia
  • interdigestive migrating contractions (IMC)