Abstract
Present review is focussed on the anti infective properties of breast milk. Breast milk is found to contain many protective factors like immunoglobulins, lysozyme, lactoperoxidase, complement components, cells and lipids. These host resistance factors act against different organisms and provide definite protection to infants from infection and reduce the mortality and morbidity rate. The practice of feeding newborns with expressed breast milk is also common in western countries. It is subjected to heat-treatment before feeding and it is found that these factors can either be destroyed or they remain stable to heat treatment depending upon the temperature and duration of exposure. Colostrum, which is secreted in first few days after birth, is different in its antiinfective properties when compared to mature milk. It contains a high amount of immunoglobulins and other non-specific factors. The preterm milk also contains higher concentrations of immunoglobulins when compared to the term milk. Therefore these serve as an initial step towards providing immunity to newborns.
Similar content being viewed by others
References
Chandra RK: Immunological aspects of human milk.Nutr Rev 36:265, 1978
Policy and codes in relation to breast feeding. (Paper presented on XVI annual meeting). Nutrition Society of India. New Delhi, 7th Oct. 1983
Jelliffe DB, Jelliffe EFP: Nutrition: pre and postnatal development. In:Human Nutrition—A comprehensive treatise. Winick M. Ed; Plenum press, New York; 247, 1979
Wenck DA, Baren M, Dewan SP: Infant Nutrition.In:Nutrition—The challenge of being well nourished. Reston publishing company, Virginia 1980. p 316
Jelliffe DB, Jelliffe EFP: Anti-infective properties of breast milk.Am J Clin Nutr 24:1013, 1971
Hanson LA, Carlsson B, Ahlstedt, Fallstrom SP: New knowledge in human milk immunology.In: New developments in pediatric research. Ghai Ed; XV International Congress of Pediatrics New Delhi, 1977 p 49
Neville MC, Neifert MR:Lactation: Physiology, nutrition and breast feeding. Academic press, New York: 1983, p249
Jelliffe DB, Jelliffe EFP:Protection and hazards In:Human milk in the modern world. II Edn; Oxford University Press, London 1979. p 84
Chandra RK: Immunology of Human milk.In:Proceeding of workshop on breast feeding and supplementary foods. Valyasevi A, Barker J. ed; United Production Press, Thailand, 1980. p 15
Blance B: Biochemical aspects of human milkcomparison with bovine milk.Wld Rev Nutr Diet 36:41, 1976
Kabara JJ: Lipids as host-resistance factors of human milk.Nutr Rev 38:65, 1980
Goldman AS, Smith CW: Host resistance factors in human milk.J Pediatr 82:1082, 1973
Ammann AJ, Stiehm ER: Immunoglobulin levels in colostrum and breast milk, and serum from formula and breast fed new borns.Proc Soc Exp Biol Med 122:1098, 1966
Ford JE, Law BA, Marshall, Valerie ME, Reiter B: Influence of heat treatment of human milk and some of its protective constitutents.J Pediatr 90: 29, 1877
Goldman AS: Human milk, leukocytes and immunity.J Pediatr 90: 167, 1977
Reddy V, Bhaskaram C, Raghuranulu N, Jagadeesan V: Antimicrobial factors in human milk.Acta Pediat Scand 66: 229, 1977
Muskicf FD: Physiological and immunological aspects of breast feeding.Cajanus 12: 202, 1979
Ananthanaryan R, Paniker CKJ: Antibodies-immunoglobulins.In:Text book of microbiology. II Edn; Orient Longman Ltd. New Delhi, 1981, p 81
Ones SU: Immunoglobulins of human colostrum and milk.J Pediatr 94:497, 1979
Mata DJ, Wyatt RG: Host resistance to infection.Am J Clin Nutr 24:976, 1971
Packard VS: Human milk and infant formula: Food science and technology—A series of monography. Academic Press London 1982. p 74
Welsh JK, May JT: Anti-infective properties of breast milk.J Pediatr 94:1, 1979
Burman D: Nutrition in early childhood. In:Text book of pediatric nutrition. McLaren DS, Burman D Ed: II Edn; Churchill livingstone, New York, 1982. p 55
Goldman AS, Garza C, Nichols B, Johnson CA, Smith EO, Goldblum RM: Effect of prematurity on the immunologic system in human milk.J Pediatr 101:901, 1982
Jolles P, Jolles J: Lysozyme from human milk.Nature 192:1187, 1961
Chandan RC, Shahani KM, Holly RG: Lysozyme content of human milk.Nature 204:76, 1964
Chandra RK, Newberne PM: Mechanisms of host defense.In:Nutrition, immunity and infection. Plenum Press, London, 1977. p 11
NIN Annual Report. NIN. Hyderabad. 1982, 93
Downham NAPS, Scott R, Sims DG, Webb JKG, Gardner PS: Breast-feeding protects against respiratory syncytial virus infection.Br Med J 2:274, 1976
Breast feeding prevents otitis media.Nutr Rev 41: 241, 1983
Winberg J, Wessne G: Does breast milk protect against septicaemia in the newborn.Lancet i: 1091, 1971
Lawton JWM, Shortridge KF: Protective factors in human breast milk and colostrum.Lancet i:253, 1977
Jelliffe DB, Jelliffe EFP: Breast milk and infection.Lancet i:1192, 1981
Goldbulm RH, Garza C, Johnson CA, Harrist R, Nichols BL, Goldman AS: Human milk banking-effects of container upon immunologic factors in mature milk.Nutr Res 1:449, 1981
Keith RM, Wood C:Infant feeding and feeding difficulties. IV Edn; J & A Churchill, London, 1971. p 50
Goldman AS, Garza C, Nichols BL, Goldblum RM: Immunologic factors in human milk during the first year of lactation.J Pediatr 100:563, 1982
Ogra SS, Ogra PL: Immunologic aspects of human colostrum and milk.J Pediatr 92:546, 1978
Gross SJ, Buckley RH, Wakil SS, MC Allister DC, David Rs, Faix RG: Elevated IgA concentration in milk produced by mothers delivered of preterm infants.J Pediatr 99:389, 1981
Chandra RK: Immunoglobulin and protein levels in breast milk produced by mothers of preterm infants.Nutr Res 2:27, 1982
Gross SJ, wakil S, David RJ, Faix RG, Rebecca: Elevated immunoglobulin IgA in milk from mothers delivering preterm infants.Pediatr Res 13:449, 1979
Differences between the immunology of term and preterm milk.Nutr Rev 41:237, 1983
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shashikala, S., Prakash, J. Anti infective properties of breast milk. Indian J Pediatr 51, 451–457 (1984). https://doi.org/10.1007/BF02776433
Issue Date:
DOI: https://doi.org/10.1007/BF02776433