Gastric ulcer and carcinoma in fundic gland area

Summary

The gastric ulcer and carcinoma in the fundic gland area were investigated with the surgically resected cases.

• 1. The frequency of the ulcer in the fundic gland area was 8.2% of 2194 cases of gastric ulcer and that of carcinoma in this area was 8.4% of 780 cases of gastric carcinoma. These two diseases showed high frequency in the age group of forty to fifty years with preponderance in female.

• 2. The ulcers in the fundic gland area usually showed high acidity and high frequency of massive bleeding like as melena and hematemesis comparing with other lesions or the ulcers in other sites.

• 3. The ratio of the low-differentiated carcinomas to the well-differentiated ones was about 3.7 to 1 in the fundic gland area and 1 to 1.3 in the pyrolic gland area.

• 4. The frequency of the early gastric carcinomas was 27% and 41% in the fundic and pyrolic gland areas, respectively.

• 5. In the fundic gland area, as observed in the pyrolic gland area, the low-differentiated carcinomas usually occurred on the non-metaplastic mucosa and the majority of well-differentiated ones were frequently found in association with the intestinal metaplasia.

• 6. Although the solitary carcinoma in the anterior wall or greater curvature was found not infrequently, the solitary ulcer was not found in these sites in this series.