Skip to main content
Log in

Studies on the etiology of milk intolerance in Japanese adults

  • Original Article
  • Published:
Gastroenterologia Japonica Aims and scope Submit manuscript

Summary

  1. 1.

    The incidence of milk intolerance is approximately 19% in Japanese adults when 200 ml of milk is given. However, a much greater incidence was assumed when considered under the criteria of Western standard.

  2. 2.

    The lactase activity was significantly greater in milk drinkers than non-drinkers. And, internation ally, the activity is higher in those nationalities whose milk consumption is greater.

  3. 3.

    Lactase is an adaptive enzyme and rather easily induced by lactose load feeding in animals. From the data of our own and of the literature, it was further confirmed that environmental factors play a more important role than genetic factors in the etio-pathogenesis of milk intolerance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Durand, P.: Lactosuria idiopathica in una paziente con diarrea cronica ed acidosi. Minerva Pediat., 10: 706–711, 1958.

    PubMed  CAS  Google Scholar 

  2. Holzel, A. et al.: Defective lactose absorption causing malabsorption in infancy. Lancet, 1 : 1126–1128, 1959.

    Article  PubMed  CAS  Google Scholar 

  3. Ferguson, A. and Maxwell, J.D.: Genetic aetiology of lactose intolerance. Lancet, 2: 188–190, 1967.

    Article  PubMed  CAS  Google Scholar 

  4. Dahlqvist, A. et al.: Intestinal lactase deficiency and lactose intolerance in adults. Gastroenterology., 45: 488–491, 1963.

    PubMed  CAS  Google Scholar 

  5. Haemmerli, U.P. et al.: Lactasemangel der Dunndarmmucosa als Ursache gewisser Formen erworbener Milchintoleranz beim Erwachsenen. Hael. Med. Acta., 30: 693–705, 1963.

    CAS  Google Scholar 

  6. Chung, M.H. and McGill, D.B.: Lactase deficiency in Orientals. Gastroenterogy., 54: 225–226, 1968.

    CAS  Google Scholar 

  7. Bolin, T.D. et al.: Lactose intolerance in Singapore. Gastroenterology., 59: 76–84, 1970.

    PubMed  CAS  Google Scholar 

  8. Sasakawa, T. and Ogoshi, K.: Studies on lactase deficiency (lactose intolerance) in adults. Diag. and Treat., 58: 1009–1017, 1970 (Japanese).

    Google Scholar 

  9. Ueda, H. et al. : Milk Intolerance in Japanese. J.Jap. Med., No. 2360: 13–18, 1969 (Japanese).

  10. Inoue, M. et al.: Lactase deficiency. Therapy, 51: 559–567, 1969 (Japanese).

    Google Scholar 

  11. Namiki, M. and Naka, K.: Milk intolerance in Ainu tribe. Jap. J. Gastroenterology, 69: 421, 1972 (Japanese).

    Google Scholar 

  12. Sasaki, G.: Intestinal lactase activity in Japanese adults. Jap. J. Gastroentetology, 68: 37–49, 1971 (Japanese).

    Google Scholar 

  13. “Sumposium on Milk Intolerance” at the 13th Annual Autumnal Meeting (1971) of The Japanese Society of Gastroenterology. Jap. J. Gastroenterology, 69: 414–424,1972 (Japanese).

  14. Newcomer, A.D. and McGill, D.B.: Disaccharidase activity in the small intestine, prevalence of lactase deficinecy in 100 healthy subjects. Gastroenterology., 53: 881–889, 1967.

    PubMed  CAS  Google Scholar 

  15. Bayless, T.M. and Rosensweig, N.S.: A racial difference in incidence of lactase deficiency. JAMA, 197: 968–972, 1966.

    Article  PubMed  CAS  Google Scholar 

  16. Welsh, J.D. et al.: Studies of lactose intolerance in families. Arch. Intern. Med. (Chicago), 122: 315–317, 1968.

    Google Scholar 

  17. Cuatrecasea, P. et al.: Lactase deficiency in the adult. A common occurrence. Lancet, 1: 14–18, 1965.

    Article  Google Scholar 

  18. Desai, H.G. et al.: Intestinal disaccharidases in tropical sprue. Gastroenterology., 53: 375–380, 1967.

    PubMed  CAS  Google Scholar 

  19. Dahlqvist, A.: Method for assay of intestinal disaccharidases. Anal. Biochem., 7: 18–25, 1964.

    Article  PubMed  CAS  Google Scholar 

  20. Lowry, O.H. et al.: Protein measurement with the folin phenol reagent. J. Biol. Chem., 193: 265–275, 1951.

    PubMed  CAS  Google Scholar 

  21. Sheehy, T.W. and Anderson, P.R.: Disaccharidase activity in normal and disease small bowel. Lancet, 7401–7404, 1965.

  22. Economic Yearbook of Dairy Firm. Dairy Economic News Agency, Tokyo, 1974 (Japanese).

  23. Creamer, B.: The Small Intestine. Heinemann Medical Books LTD, London, 1974.

    Google Scholar 

  24. Matsunaga, F.: Lactase deficiency. J. Clin. Science, 4: 1000–1003, 1968 (Japanese).

    Google Scholar 

  25. Yoshida, Y.: Jejunal disaccharidase activity. Jap. J. Gastroent., 66: 499–450, 1969 (Japanese).

    Google Scholar 

  26. Goto, S.: Disaccharidase activity in the jejunal mucosa. Jap. J. Int. Med., 62: 747–755, 1973 (Japanese).

    CAS  Google Scholar 

  27. Yoshida, Y. et al.: Lactose intolerance in Japanese adults. The 9th International Congress of Gastroenterology (Paris), 1972.

  28. Shibuya, Y. et al.: Lactose tolerance in Japanese. Igaku No Ayumi, 72: 323–324, 1970 (Japanese).

    Google Scholar 

  29. Haemmerli, U.P, et al.: Acquired milk intolerance in the adult caused by lactose malabsorption due to a selective deficiency of intestinal lactase activity. American Jounal of Medicine, 38: 7–30, 1965.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yoshida, Y., Sasaki, G., Goto, S. et al. Studies on the etiology of milk intolerance in Japanese adults. Gastroenterol Jpn 10, 29–34 (1975). https://doi.org/10.1007/BF02775921

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02775921

Key words

Navigation