Summary
We report a case of a 53-year-old woman with adult T-cell leukemia/lymphoma (ATL) (lymphoma type) with multiple gastric lesions, admitted to our hospital because of systemic lymphadenopathy and epigastralgia. Gastroscopy showed a variety of gastric lesions including thickened folds, ulcerations and polypoid lesions. Biopsy specimens obtained from the stomach and lymph nodes revealed diffuse infiltration of pleomorphic mononuclear cells and the integration of HTLV-1 proviral DNA. We demonstrated through the investigation of 30 previously reported cases of ATL that this is a rare case of the lymphoma type of ATL presenting remarkable gastric lesions.
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Takatsuki K, Uchiyama T, Ueshima Y, et al: Adult T-cell leukemia: Proposal as a new desease and cytogenetic, phenotypic and functional studies of leukemic cells. In: Hanaoka M, Takatsuki K, Shimoyama M, eds. Adult T Cell Leukemia and Related Diseases. Tokyo: Japanese Scientific Societies Press. 1974; 13–22.
Kubonishi I, Daibana M, Yano S, et al: Gastric lymphoma associated with human T-cell leukemia virus type I. Arch Intern Med 1987;147:603–605.
Obata S, Matsuzaki H, Nishimura H, et al: Gastroduodenal complications in patients with adult T-cell leukemia. Jpn J Clin Oncol 1988;18:335–342.
Utsunomiya A, Hanada S, Terada A, et al: Adult T-cell leukemia with leukemia cell infiltration into the gastrointestinal tract. Cancer 1988;61:824–828.
Otsuka M, Utsunomiya A, Makino T, et al: Clinicopathological studies of the gastrointestinal tract in adult T-cell leukemia patients. Acta Haematol Jpn 1989;52:623–629.
Pinkus GS, O’hara CJ, Said JW: Peripheral/post-thymic T-cell lymphoma: a spectrum of disease. Clinical, pathologic, and immunologic features of 78 cases. Cancer 1990;65:971–998.
Davis GL, Dibner MD, Battey JF: DNA preparation from cultured cells and tissue. In: Basic Methods in Molecular Biology. New York: Elsevier. 1986;47–50.
Fujita K, Izumi Y, Sawada H, et al: Cytogenetic study on the adult T-cell leukemia. Jpn J Clin Hematol 1987;28:1385–1393. (in Japanese)
Shimamoto Y, Ohno K. Sano M, et al: Differences in prognostic factors between leukemia and lymphoma type of adult T-cell leukemia. Cancer 1989;63:289–294.
Sato E, Hasui K. Tokunaga M: Autopsy findings of adult T-cell lymphoma/leukemia. Gann Monogr Cancer Res 1982;28:51–64.
Shimoyama M, Minato K, Saito H, et al: Non T-cell lymphoma and chronic lymphocytic leukemia-immunologic and clinicopathologic study. Jpn J Clin Oncol 1980;10:241–254.
Obata S, Maeda K, Sato M, et al: Gastrointestinal involvement of adult T-cell leukemia. Gastroenterol Endosc 1989;31:3390. (in Japanese)
Obata S, Tsukamoto A, Kimura K, et al: Adult T-cell leukemia presenting a IIa+IIc—like lesion in the stomach on endoscopie examination. Endoscopy 1990;22:81–82.
Abe T, Saito Y, Sato H, et al: A case of adult T-cell leukemia/lymphoma (ATL) with gastric lesions. Gastroenterol Endosc 1988;30: 1807–1812. (in Japanese)
Yamamoto N, Yamaguchi H, Takenaka T, et al: A case of adult T-cell leukemia (ATL) with gastric involvement. Prog Digest Endosc 1987;30:275–278. (in Japanese)
Nakasone A, Masuda M, Arakaki H, et al: Adult T-cell leukemia with massive melena due to marked gastrointestinal involvement. Jpn J Clin Hematol 1989;30:1848–1852. (in Japanese)
Kitai K, Itoh Y, Suzuki S, et al: A case of ATL with gastric involvement difficult to be diagnosed. Gastroenterol Endosc 1988;30: 795. (in Japanese)
Takagi S, Mizumoto G, Shimomura S, et al: A case of ATL with multiple gastric involvement. Jpn J Gastroenterol 1988;85:2298. (in Japanese)
Kubonishi I, Miyoshi I: A case of ATL (lymphoma type) with gastric involvement as a primary focus. Biomedicine and Therapeutics 1989;22:227–229. (in Japanese)
Tago K, Hirakawa M, Yoshinari M, et al: A case of adult T-cell leukemia with gastric symptoms at the onset. Jpn J Clin Exp Med 1987;64:2153–2158. (in Japanese)
Makino T, Terada A, Kodama M, et al: Two cases of adult T-cell leukemia with gastric lesions similar to those of Borrmann II gastric cancer. Jpn J Clin Exp Med 1989;66:3827–3831. (in Japanese)
Itoh I, Imamura K, Tagawa M, et al: Clinicopathological studies of gastrointestinal lesions in adult T-cell leukemia/lymphom. Jpn J Clin Exp Med 1988;65:857–860. (in Japanese)
Maruyama S, Daito K, Watanabe H, et al: A case of adult T-cell leukemia/lymphoma with gastric involvement. Gastroenterol Endosc 1989;31:2245–2246. (in Japanese)
Saito Y, Morise K: A case of adult T-cell leukemia with upper gastrointestinal lesions. Gastroenterol Endosc 1989;31:1701. (in Japanese)
Tashiro K, Nakao S. Noguchi K, et al: A case of adult T-cell leukemia/lymphoma with gastric involevement. Geka Shinryo 1987; 10:1373–1376. (in Japanese)
Nelson RS, Lanza FL: Benign and malignant tumors of the stomach (other than carcinoma). In: Berk JE, ed. Bockus Gastroenterology. Saunders, Philadelphia. 1985;1255–1267.
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Katabami, S., Hinoda, Y., Ohe, Y. et al. Adult T-cell leukemia/lymphoma (lymphoma type) with remarkable gastric lesions: A case report. Gastroenterol Jpn 27, 95–101 (1992). https://doi.org/10.1007/BF02775070
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DOI: https://doi.org/10.1007/BF02775070