Summary
When lymph node cells from sensitized guinea pigs were stimulated in vitro with a specific antigen and their culture supernatant was injected into the mesenteric vein of rats, a marked decrease in bile flow was demonstrated. The treatment of activated lymphocytes with a higher molecular weight fraction of normal human serum Fr-1 and Fr-2 was shown to decrease the reduction of bile flow. Conversely, a lower molecular weight fraction of serum (Fr-3) was found to augment the reduction of bile flow. These findings suggest that the serum components may regulate the production of a factor (or factors) causing the decrease in bile flow from the activated lymphocytes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Mizoguchi Y, et al: Studies on drug-induced allergic intrahepatic cholestasis—Hepatic cholestasis induced in dogs by lymphocyte culture supernatant. Gastroenterologia Jpn 14: 19, 1979
Mizoguchi Y, et al: Partial purification of the cholestatic factor. Gastroenterology 79: 1040, 1980
Mizoguchi Y, et al: Studies on intrahepatic cholestasis in drug-induced allergic hepatitis: Intrahepatic cholestasis induced in rat by the culture supernatant of activated lymphocytes. Hepato-gastroenterology 28: 147, 1981
Mizoguchi Y, et al: Studies on intrahepatic cholestasis-Intrahepatic cholestasis in rats by the culture supernatant of activated lymphocytes. Hepato-gastroenterology 28:292, 1981
Mizoguchi Y, et al: Partial purification of the cholestatic factor derived from the lymphocytes of tuberculin-sensitized guinea pigs. Gastroenterologia Jpn 16: 260, 1981
Mizoguchi Y, et al: Participation of cholestatic factor in the pathogenesis of intrahepatic cholestasis in acute viral hepatitis. Jpn J Gastroenterology 78: 1628, 1981
Mizoguchi Y, et al: Modulation of the macrophage hepatocytotoxicity and plasminogen activator of activated macrophages by serum components from normal human and patients with liver diseases. Jpn J Medicine 22: 112, 1983
Chapman HAJr, et al: Modulation of plasminogen activator secretion by activated macrophages: Influence of serum factors and correlation with tumoricidal potential. Proc Natl Acad Sci 76: 3899, 1979
Schreier MH: The antibody response in vitro: Dissection of complex system. Lymphokines2: 31, 1981
Schreier MH, Nordin AA: An evaluation of the immune response in vitro. B and T cells in immune recognition. Edited by Loor F, Roelants GE, John Wiley and Sons Ltd, p 127, 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mizoguchi, Y., Sakagami, Y., Sawai, H. et al. Modulation of cholestatic factor production by serum components. Gastroenterol Jpn 18, 372–376 (1983). https://doi.org/10.1007/BF02774955
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774955