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Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachlorideintoxicated rats

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Summary

Tyrosine hydroxylase activity in the corpus striatum was measured in a large dose of carbon tetrachloride (CCl4)-intoxicated rats in order to confirm whether brain catecholamine contents decrease in acute hepatic failure or not. Theoretical amounts of dopa synthesized in the brain of the treated animals were calculated according to an equation of enzyme kinetics. Tyrosine hydroxylase activities in CCl4-injured rats were similar to those in control rats, and calculated amounts of brain dopa in liver-injured rats were rather higher as compared to those in untreated animals.

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Authors and Affiliations

  1. The First Department of Internal Medicine, Okayama University Medical School, 2-5-1, Shikata-cho, 700, Okayama, Japan

    Nobuyuki Takei M.D., Akiharu Watanabe M.D., Tatsuro Sakata M.D., Shosaku Hayashi M.D., Takahiro Obata M.D., Tetsuya Shiota M.D. & Hideo Nagashima M.D.

Authors
  1. Nobuyuki Takei M.D.
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  2. Akiharu Watanabe M.D.
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  3. Tatsuro Sakata M.D.
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  4. Shosaku Hayashi M.D.
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  5. Takahiro Obata M.D.
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  6. Tetsuya Shiota M.D.
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  7. Hideo Nagashima M.D.
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Takei, N., Watanabe, A., Sakata, T. et al. Brain tyrosine hydroxylase activity and calculated amount of brain dopa synthesized in carbon tetrachlorideintoxicated rats. Gastroenterol Jpn 18, 11–14 (1983). https://doi.org/10.1007/BF02774854

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  • DOI: https://doi.org/10.1007/BF02774854

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