Summary
Serum activities of LDH isoenzymes as well as total LDH, GOT and GPT were determined after hepatic artery ligation in five patients with primary or metastatic liver cancer. Transaminases and total LDH activities were raised after the operation showing their peaks on the first or third postoperative days. LDH2, LDH3 and LDH5 increased substantially during the first three postoperative days. These changes became nearly normalized within two weeks after hepatic artery ligation. As control the same enzymatic activities were measured in eight patients after usual laparotomies but no significant abnormalities were observed postoperatively. Thus, liberation of not only cathodic but also anodic migrating LDH isoenzymes seems to ensue possibly after acute liver damage induced by hepatic artery ligation. This study also suggests that serial determination of LDH isoenzymes as well as its total activity could be a valuable assessment for evaluating the anti-tumor effect of hepatic artery ligation.
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References
Wroblewski, F.: Lactic dehydrogenase isoenzymes and the distribution in normal tissues and plasma. Ann. N. Y. Acad. Sci., 94: 912–932, 1961.
Wroblewski, F. and Ladue, J.S.: Lactic dehydrogenase activity in blood. Proc. Soc. Exp. Med., 90: 210–213, 1955.
Zimmerman, H.J. and Weinstein, B.S.: Lactic dehydrogenase activity in human serum. J. Lab. Clin. Med., 48: 607–616, 1956.
Preston, J.A., Briere, R.O. and Batsakis, J.G.: Rapid electrophoretic separation of lactic dehydrogenase isoenzymes on cellulose acetate. Am. J. Clin. Pathol., 43: 256–260, 1965.
Wienie, R.H.: The fifth LDH isoenzyme as an index of liver injury. Ann. N.Y. Acad. Sci., 94: 898–911, 1961.
Wright, E.J., Cauley, L.P. and Eberhardt, L.: Clinical application and interpretation of the serum lactic dehydrogenase zymogram. Am. J. Clin. Pathol., 45: 737–745, 1966.
Batsakis, J.G., Briere, R.O. and Preston, J.A.: Clinical enzymology. Univ. Mich. Med. Ctr., 30: 278–282, 1964.
Batsakis, J.G. and Siders, D.: Enzyme molecular heterogeneity (isoenzymes) in surgical diagnosis. Arch. Surg., 95: 138–143, 1967.
Starkweather, W.H., Spencer, H.H., Schwarz, E.L. and Schoch, H.K.: The electrophoretic separation of lactate dehydrogenase isoenzymes and their evaluation in clinical medicine. J. Lab. Clin. Med., 67: 329–343, 1966.
Goldman, R.D., Kaplan, N.O. and Hall, T.C.: Lactic dehydrogenase in human neoplastic tissues. Cancer Res., 24: 389–399, 1964.
Massey, W.H., Dennis, D.L., Fletcher, W.S. and Wood, D.C.: Lactic dehydrogenase isoenzyme alterations in malignant disease of the liver. Am. J. Surg., 122: 209–216, 1971.
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Nagasue, N. Changes in lactic dehydrogenase isoenzymes after hepatic artery ligation in patients with hepatic carcinoma. Gastroenterol Jpn 10, 150–156 (1975). https://doi.org/10.1007/BF02774843
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DOI: https://doi.org/10.1007/BF02774843