Summary
The secretin-like activity contained in bioptic specimens of duodenal mucosa was measured by means of bioassay in healthy controls and patients of peptic ulcer. It was found that the activity tended to be increased in duodenal ulcer in comparison with gastric ulcer which did not differ from healthy controls, Possibilities of impaired release and/or increased production of secretin-like substance in duodenal ulcer were discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Love, J.W.: Secretin-A neglected key? Gastroenterology, 59: 147–148, 1970.
Poth, E.J. and Gold, D.: Peptic ulcération-Physiological evaluation of the influence of duodenal acidification. Ann. Surg., 169: 777–783, 1969.
Bochenek, W., Rodgers, J.B. and Balint, J.A.: Inhibition of pentagastrin-stimulated gastic secretion by duodenal acidification or administration of fat in normal subjects and in patients with duodenal ulcer. Amer. J. Digest. Dis., 16: 865–872, 1971.
Johnston, D. and Dathie, H.L.: Effect of acid in the duodenum on histamine stimulated gastric secretion in man. Gut, 5: 573–580, 1964.
Wormsley, K.G.: Response to duodenal acidification in man-1. Electrolyte changes in the duodenal aspirate.Scand. J. Gastroent., 4: 717–726, 1969.
Love, J.W.: A method for the assay of secretin using rats. Q. J. exp. Physiol., 42: 279–284, 1957.
Tachibana, S.: The bioassay of secretin in the rat. Japan. J. Pharmacol., 21: 325–336, 1971.
Tachibana, S.: Secretin and cholecystokininpancreozymin -Their bioassay and purification. Gastroentero-pancreatic endocrine system edited by T. Fujita, Igakushoin Co., Tokyo: 174–192, 1973.
Konturek, S.J., Tasler, J. and Obtulowics, W.: Localization of secretin release by acid in small intestine of the dog. Amer. J. Physiol., 220: 124–127, 1971.
Dockray, G.J.: The action of secretin, cholecystokinin-pancreozymin and caerulein on pancreatic secretion in the rat. J. Physiol., 225: 679–692, 1972.
Rune, S.J. and Worning, H.: The pancreatic response to instillation of acid into the duodenum and to exogenous secretin in man. Scand. J. Gastroent., 6: 291–296, 1970.
Wormsley, K.G.: Response to duodenal acidification in man-III. Comparison with the effects of secretin and pancreozymin. Scand. J. Gastroent., 5: 353–360, 1970.
Bloom, S.R. and Ward, A.S.: Secretin release in man after intraduodenal acid. Gut, 15: 338, 1974.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishimori, A., Takebe, T., Mita, M. et al. Secretin-like activity in duodenal mucosa and peptic ulcer. Gastroenterol Jpn 10, 146–149 (1975). https://doi.org/10.1007/BF02774842
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774842