Compartmenal analysis of indocyanine green transport in normal subjects and patients with hepatic dysfunction

Summary

The plasma disappearance curve following a single intravenous injection of Indocyanine Green (ICG) was analyzed by an established technique and ICG kinetics evaluated for 12 normal control subjects and 57 patients with various hepatic disorders. The two-compartment model was used in this analysis. Three fractional transport rates were determined for the two-pool system: (1) fractional hepatic removal rate; (2) fractional hepatic plasma reflux rate; (3) fractional biliary secretory rate. The mean values and their standard deviation for the three respective rate in normal subjects are: (1) 0.2168 ±0.0199 min^-1; (2) 0.0136 ±0.0089 min^-1; (3) 0.0642 ±0.0327 min^-1. The respective mean rates for 25 patients with biopsy proved hepatic cirrhosis are: (1) 0.0777 ±0.0388 min^-1; (2) 0.0127 ±0.0081 min^-1; (3) 0.0434 ±0.0188 min^-1. The respective means for 7 patients in the acute phase of acute viral hepatitis are: (1) 0.1066 ±0.0498 min^-1; (2) 0.0078 ±0.0046 min^-1; (3) 0.0218 ±0.0141 min^-1. The respective means for 6 patient with almost complete biliary obstruction are: (1) 0.0503 ±0.0211min^-1; (2) 0.0717 ±0.0103 min^-1; (3) 0.0422 ±0.0190 min^-1. Changes in these parameters were dtermined in acute phase and convalescent phase of acute viral hepatitis. This kinetic approach was compared with previous evaluation of sulfobromophthalein (BSP) transport in man and similar results were obtained for the two dyes in normal subjects and in cirrhotic patients.