Summary
We examined the maximal serum PABA concentration within 3 hrs (MS-PABA) and the 6 hr urinary PABA recovery (6 hr U-PABA) after BT-PABA administration, PABA excretion index, and chymotrypsin secretory response to caeruleinsecretin stimulation in ten control subjects and fifteen patients with chronic pancreatitis diagnosed on the basis of pancreatograms. The results suggested that MS-PABA can distinguish the patients with definite irregular dilatation of the main pancreatic duct from the controls, but not those with localized irregular dilatations of the side branches from the controls. MS-PABA showed a significant correlation with 6 hr U-PABA, PABA excretion index, chymotrypsin output and bicarbonate output. This modified method was shown to be useful in the diagnosis of chronic pancreatitis with unequivocally abnormal pancreatograms and/or markedly decreased chymotrypsin secretion. This modification will serve to simplify the BT-PABA test by eliminating urinary collection and shortening the procedure time.
Similar content being viewed by others
References
Mitchell CJ, et al: Improved diagnostic accuracy of a modified oral pancreatic function test. Scand J Gastroent 14: 737, 1979
Tetlow VA, et al: A one-day oral pancreatic function test using a chymotrypsin-labile peptide and a radioactive marker. Clinical Trials Journal 17: 121, 1980
Dockter G, et al: Determination of protease-cleaved paminobenzoic acid (PABA) in serum after oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid (PABA-peptide) in children. Eur J Pediatr 135: 277, 1981
Breau JP, et al: Le test à l’acide para-aminobenzoïque dans les pancréatites chroniques. Nouv Presse Med 10: 3631, 1981
Bornschein W: Der PABA-Peptide-Serum-Test, Untersuchungen zur methodischen Verbesserung eines indirekten Pankreasfunktionstests. DTsch med Wschr 106: 1676, 1981
Wolf Ch, et al: Paraaminobenzoesäurespiegel im Serum nach Gabe von N-Benzoyl-L-tyrosyl-Paraaminobenzoesäure als Suchtest der exkretorischen Pankreasfunktion. Schweiz med Wschr 111: 343, 1981
Delchier JC, et al: BT-PABA test with plasma PABA measurements: evaluation of sensitivity and specificity. Gut 24: 318, 1983
Lang C, et al: Value of serum PABA as a pancreatic function test. Gut 25: 508, 1984
Smith HW, et al: The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man. J Clin Invest 24: 388, 1945
Erlanger BF, et al: The action of chymotrypsin on two new chromogenic substrates. Arch Biochem Biophys 115:206, 1966
Wallenstein S, et al: Some statistical methods useful in circulation research. Circulation Res 47: 1, 1980
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Myoen, R., Takebe, T. & Ohyama, K. The usefulness of serum paba measurement after bt-paba administration in the diagnosis of chronic pancreatitis. Gastroenterol Jpn 20, 457–464 (1985). https://doi.org/10.1007/BF02774783
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774783