Summary
A comparative study of chronic hepatitis in two hospitals in Japan and England is reported. Patients seen in England came from a variety of countries and races. Type B chronic hepatitis was common in both hospitals. While CPH, CLH, and mild CAH were more frequently seen in cases from England, two thirds of the cases from Japan showed moderate or severe CAH. The most striking differences among the histological features were plasma cell infiltration and lymphoid follicle formation. The former was more frequent and conspicuous in cases from England, and the latter in non-A non-B cases from Japan. The incidence of bile duct damage and granulomatous lesions was different in the two hospitals. It was concluded that geographical differences should be taken into account when pathogenesis, histological definition, treatment and many other aspects of chronic hepatitis are assessed.
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References
Review by an International Group: Acute and chronic hepatitis revisited. Lancet ii: 914, 1977
Scheuer PJ: Chronic hepatitis. In: Liver Biopsy Interpretation. 3rd Edition, Bailliere Tindall, London, 1980, p 102
Scheuer PJ: Primary biliary cirrhosis. Proceedings of the Royal Society of Medicine 60: 1257, 1967
Oda T, et al: Non-A non-B hepatitis in Japan. In: Non-A, non-B hepatitis Edited by Gerety. Academic Press, New York, 1981, p 153
Gitnick GL, et al: Australia antigen in chronic active liver disease and cirrhosis. Lancet ii: 285, 1969
Reed WD, et al: Detection of hepatitis B antigen by radioimmunoassay in chronic liver disease and hepatocellular carcinoma in Great Britain. Lancet ii: 690, 1973
Cooksley WGE, et al: Australia antigen in acute and chronic hepatitis in Australia. Aust NZ J Med 2: 261, 1972
Bianchi P, et al: Occurrence of Australia antigen in chronic hepatitis in Italy. Gastroenterology 63: 482, 1972
Van Waes, et al: Chronic liver disease and hepatitis B antigen: a prospective study. Br Med J 3: 444, 1974
Page AR, Good RA: Plasma cell hepatitis. Lab Invest 11:288, 1960
Poulsen H, Christoffersen: Abnormal bile duct epithelium in chronic aggressive hepatitis and cirrhosis. A review of morphology and clinical biochemical and immunologic features. Human Pathol 3: 317, 1972
Bamber M, et al: Clinical and histological features of a group of patients with sporadic nonA, nonB hepatitis. J Clin Pathol 34: 1175, 1981
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Inoue, K. Comparative study of chronic hepatitis: histological differences between Japan and England. Gastroenterol Jpn 20, 222–228 (1985). https://doi.org/10.1007/BF02774708
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DOI: https://doi.org/10.1007/BF02774708