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Hypercholinesterasemia in patients with hepatocellular carcinoma: A new paraneoplastic syndrome

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Summary

Two cases of hepatocellular carcinoma (HCC) were described, in whom hypercholinesterasemia was found. Histochemical examinations revealed that there was a significantly increase in enzyme activity of cholinesterase in liver tissue slice obtained from the part of carcinoma in case 1. It was found that cholinesterase activity in homogenized liver tissue in part of carcinoma was much higher than that of non-carcinoma, and even in other HCC cases, hepatic cirrhosis and control liver tissues. These results suggested that HCC cells were capable of producing cholinesterase and, therefore, that hypercholinesterasemia was an additional paraneoplastic syndrome in HCC.

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Authors and Affiliations

  1. 3rd Department of Internal Medicine, Kumamoto University School of Medicine, 1-1-1 Honjo, 860, Kumamoto City, Japan

    Junichi Tajiri M.D., Yasufumi Nishizono M.D., Shigetoshi Fujiyama M.D., Katsuro Sagara M.D., Tatsuo Sato M.D. & Hisao Shibata M.D.

  2. Gastroenterology Unit of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    Hisao Shibata M.D.

Authors
  1. Junichi Tajiri M.D.
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  2. Yasufumi Nishizono M.D.
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  3. Shigetoshi Fujiyama M.D.
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  4. Katsuro Sagara M.D.
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  5. Tatsuo Sato M.D.
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  6. Hisao Shibata M.D.
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Tajiri, J., Nishizono, Y., Fujiyama, S. et al. Hypercholinesterasemia in patients with hepatocellular carcinoma: A new paraneoplastic syndrome. Gastroenterol Jpn 18, 137–141 (1983). https://doi.org/10.1007/BF02774688

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  • DOI: https://doi.org/10.1007/BF02774688

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