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Ranking of liver tests for differential diagnosis of liver parenchymal diseases

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Summary

Liver function tests were ranked in the order useful to differentiate 8 liver parenchymal diseases in combination of tests by forward selection and backward elimination procedures in the likelihood method using a microcomputer. The orders were almost same in both procedures: indocyanine green plasma disappearance rate, glutamic pyruvic transaminase (GPT), zinc turbidity test, alkaline phosphatase, age, HBsAg, RA test, glutamic oxaloacetic transaminase (GOT)/GPT ratio, GOT, cholesterol, total protein, total bilirubin, albumin/globulin ratio and γ-globulin. The first 9 tests had almost all informations of all tests. The first likelihood diagnosis using the 9 tests was correct in 53% and the first or the second diagnosis was correct in 71 % of 444 cases of 8 liver parenchymal diseases. A score table of likelihood diagnosis using the 9 tests was presented for manual application to new cases.

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Authors and Affiliations

  1. First Department of Internal Medicine, Okayama University Medical School, Shikata-cho, 2-5-1, 700, Okayama, Japan

    Tatsuya Itoshima M.D., Kenji Kawaguchi M.D., Shigeru Morichika M.D., Toshio Ito M.D., Shozo Kiyotoshi M.D., Hiromichi Ogawa M.D., Shiro Yuasa M.D., Shuzo Hattori M.D., Masahiro Kitadai M.D., Shigeki Mizutani M.D., Minoru Ukida M.D. & Hideo Nagashima M.D.

Authors
  1. Tatsuya Itoshima M.D.
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  2. Kenji Kawaguchi M.D.
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  3. Shigeru Morichika M.D.
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  4. Toshio Ito M.D.
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  5. Shozo Kiyotoshi M.D.
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  6. Hiromichi Ogawa M.D.
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  7. Shiro Yuasa M.D.
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  8. Shuzo Hattori M.D.
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  9. Masahiro Kitadai M.D.
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  10. Shigeki Mizutani M.D.
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  11. Minoru Ukida M.D.
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  12. Hideo Nagashima M.D.
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Itoshima, T., Kawaguchi, K., Morichika, S. et al. Ranking of liver tests for differential diagnosis of liver parenchymal diseases. Gastroenterol Jpn 18, 109–113 (1983). https://doi.org/10.1007/BF02774684

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  • DOI: https://doi.org/10.1007/BF02774684

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