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Alterations in levels of apolipoprotein C-III and C-II/C-III ratios in patients with liver disease

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Summary

Apolipoprotein (apo) C-III levels and relative proportions of apo C-II and apo C-III were determined in patients with liver disease in attempts to show the relationship between abnormalities in lipoprotein metabolism and liver function. The levels of apo C-III decreased in most patients with liver disease except cases with fatty liver or cholestasis. The levels of apo C-III correlated with some liver function parameters such as albumin but not with triglyceride concentrations. The C-II/C-III ratios were higher in patients with liver disease, a decrease in apo C-III-1 being most prominent. Estimation of the levels of apo C-II suggested that the C-II levels would not be impaired in most of patients with liver disease, despite a decrease in apo C-III levels.

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Authors and Affiliations

  1. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, 812, Fukuoka, Japan

    Shunichi Koga M.D., Kyosuke Yamamoto M.D. & Hiroshi Ibayashi M.D.

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  1. Shunichi Koga M.D.
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  2. Kyosuke Yamamoto M.D.
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  3. Hiroshi Ibayashi M.D.
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Koga, S., Yamamoto, K. & Ibayashi, H. Alterations in levels of apolipoprotein C-III and C-II/C-III ratios in patients with liver disease. Gastroenterol Jpn 19, 65–71 (1984). https://doi.org/10.1007/BF02774648

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  • DOI: https://doi.org/10.1007/BF02774648

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