Summary
Twenty Syrian golden hamsters received weekly injections of pancreatic cancer inducing DHPN. Their Poly (U) specific serum RNase levels were significantly elevated when compared to the control levels. Following salt fractionation, Poly (U) specific activity was present in both the 40% and 50% salt saturated fractions. Tissue assays showed that Poly (U) specific RNase was present in both pancreas and liver tissue extract, although the liver tissue RNase had a different pH maximum than that of the serum RNase.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Fraumeni JFJr: Cancers of the pancreas and biliary tract: epidemological considerations. Cancer Res 35: 3437–3446, 1975
Reddi KK, Holland JF: Elevated serum ribonuclease in patients with pancreatic cancer. Proc Nati Acad Sei USA 73: 2308–2310, 1976
Nakazawa S, et al: Experimental study of the pancreatic carcinoma induced by the administration of di-isopropanolnitrosamine. Jpn J Gastroenterol 74: 581–588, 1977
Kajikawa M: Studies of DHPN induced pancreatic carcinoma with emphasis of pancreatography. Jpn J Gastroenterol 75: 1386–1398, 1978
Pour P, et al: Cancer of the pancreas induced in the Syrian golden hamster. Am J Pathol 76: 349–358, 1974
Pour P, et al: A new approach for induction of pancreatic neoplasms. Cancer Res 35: 2259–2268, 1975
Reber HA, et al: Pancreatic secretion in hamsters with pancreatic cancer. Surgery 82: 34–41, 1977
Reddi KK: Nature and possible origin of human serum ribonuclease. Biochem Biophys Res Commun 67: 110–118, 1975
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Walton, D., Nakazawa, S., Kajikawa, M. et al. RNase Levels in golden hamsters with dhpn induced pancreatic cancer. Gastroenterol Jpn 14, 74–79 (1979). https://doi.org/10.1007/BF02774607
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774607