Summary
To evaluate diagnostic usefulness for pancreatic cancer, serum ribonuclease (RNase) level was determined in the three groups of subjects; 1) normal volunteers as control, 2) patients with histologically determined pancreatic cancer, and 3) patients with miscellaneous diseases other than pancreatic cancer.
A small increase of RNase values was recognized with age in the normal subjects and in the patients with nonpancreatic diseases, if renal function was normal. The mean RNase level in the control subjects was 97±41.2units.
A marked elevation of serum RNase level was demonstrated in the patients with pancreatic cancer (p< 0.001) and in the patients with renal dysfunction, but no significant rise was noticed in the patients with pancreatitis. Mean values of RNase in the patients with pancreatic cancer and renal dysfunction were 368±146 units and 342±78.1 units respectively. RNase values above 300 units were recognized in 15(71%)out of 21 patients with pancreatic cancer.
Seven cases with elevated RNase over 300 units other than non-pancreatic malignancy and renal dysfunction were noticed in 6 instances of obstructive jaundice and in one instance of early gastric cancer (an 84-yearold male).
The above-stated findings indicate that serum RNase determination can be utilized as a diagnostic indicator for pancreatic cancer.
Similar content being viewed by others
References
Metais P, et al: Activite ribonucleasique du serum humain. Bull Soc Chim Biol (Paris) 37: 999, 1955
Houck JC, et al: Serum ribonuclease activity. J Appl Physiol 12: 473, 1958
Migliarese JF: Serum ribonuclease in the cancer patient. Proc Am Assoc Cancer Res 2: 327, 1958
Rabinovitch M, et al: Plasma ribonuclease activity in human uremia. J Lab Clin Med 53: 563, 1959
Hisada T: Changes of ribonuclease activity in serum and urine during the course of surgical treatment for the diagestive organ cancer and other diseases. Iryo 23: 615, 1969 Jpn)
Ressler N, et al: Investigation of ribonuclease isozymes by an electrophoretic ultra-violet method. Nature 210: 695, 1966
Zytko J, et al: Serum ribonuclease in patients with malignant disease. Can Med Assoc J 86: 482, 1962
Chretien PB, et al: Serum ribonucleases in cancer: Relations to tumor histology. Cancer 31: 175, 1973
Levy AL, et al: Serum ribonuclease levels in malignant and nonmalignant diseases. (abstr.) Proc Am Assoc Cancer Res 3: 36, 1959
Levy AL, et al: Effect of disease states on the ribonuclease concentration of body fluid. Clin Chem 6: 43, 1960
Aleksandrowicz J, et al: Disorders of ribonuclease activity in chronic granulocytic leukemia. (cited from 8) Acta Med Pol 7: 299, 1966
Udolf E, et al: Activity of nucleases in plasmocytic reticuloma. Pol Tyg Lek 23: 640, 1968 (cited from 8)
Fink K, et al: Serum ribonuclease in multiple myeloma. Am J Med 50: 450, 1971
Roth JS: Ribonuclease VII. Partial purification and characterization of a ribonuclease inhibitor in rat liver supernatant. J Biol Chem 231: 1085, 1958
Rahman YE: Existence of a third ribonuclease in rat liver particulates. Biochem Biophys Acta 119: 470, 1966
Carter BG, et al: Immunochemical analysis of the multiple forms of bovine ribonuclease. Ann NY Acad Sei 94: 1004, 1961
Albinus RN: Isolation of salivary ribonuclease, deoxyribonuclease and amylase from the parotid gland of the rat. Biochem Biophys Acta 341: 305, 1974
Frank JJ, et al: Properties of a human liver ribonuclease. J Biol Chem 251: 5745, 1976
Reddi KK: Human granulocyte ribonuclease. Biochem Biophys Res Commun 68: 1119, 1976
Reddi KK: Nature and possible origin of human serum ribonuclease Biochem Biophys Res Commun 67: 110, 1975
Reddi KK, et al: Elevated serum ribonuclease in patients with pancreatic cancer. Proc Nat Acad Sei USA 73: 2308, 1976
Connolly JH, et al: Ribonuclease in normal and uremic human blood. Brit J Exp Path 43: 402, 1962
Shenkin A, et al: An assessment of the clinical usefulness of plasma ribonuclease assays. Clin Chim Acta 72: 223, 1976
Coombes EJ, et al: Age and sex related reference values for serum ribonuclease. Clin Chim Acta 79: 271, 1977
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nakane, H., Yoshida, M. & Murakami, T. Assessment of the clinical usefulness of serum ribonuclease assays: An indicator for the detection of pancreatic cancer. Gastroenterol Jpn 14, 55–62 (1979). https://doi.org/10.1007/BF02774605
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774605