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Gastric emptying in normal subjects and patients with peptic ulcer

A study using the acetaminophen method

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Summary

Gastric emptying in patients with peptic ulcer and normal subjects was studied using the acetaminophen method. The subjects consisted of 15 normal subjects, 52 gastric ulcer patients and 65 duodenal ulcer patients, who were studied in active stage of the ulcer. As an indicator of gastric emptying rate, the plasma acetaminophen concentration was measured by dye method (diphenylhydrazyl), as meg/ml, at 45 minutes after ingestion of a high calory pasty test meal (200 ml) with 1.5gr of acetaminophen.

In normal subjects, the plasma acetaminophen concentration was 9.4±3.6mcg/ml. In gastric ulcer patients, the concentration was 7.4±3.2mcg/ml, which showed significantly delayed gastric emptying (P< 0.05). In duodenal ulcer patients, the concentration was 11.6±3.3mcg/ml, which suggested significantly rapid gastric emptying (P< 0.05).

In consideration of gastric acid secretion, gastric ulcer cases with lower acid secretion have more delayed gastric emptying. In duodenal ulcer cases with hypersecretion, gastric emptying is more rapid than normoand/or hyposecretory cases (P< 0.005).

The delayed gastric emptying may play a role in etiology of gastric ulcer. On the other hand, the rapid gastric emptying with gastric acid hypersecretion may be important in the pathogenesis of duodenal ulcer.

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Authors and Affiliations

  1. Department of Internal Medicine School of Medicine, Tokai University, 259-11, Boseidai, Isehara, Kanagawa, Japan

    Shigeru Harasawa M.D., Norio Tani M.D., Sotaro Suzuki M.D., Masahiko Miwa M.D., Ryuichi Sarita M.D., Tetsu Nomiyama M.D. & Takeshi Miwa M.D.

Authors
  1. Shigeru Harasawa M.D.
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  2. Norio Tani M.D.
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  3. Sotaro Suzuki M.D.
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  4. Masahiko Miwa M.D.
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  5. Ryuichi Sarita M.D.
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  6. Tetsu Nomiyama M.D.
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  7. Takeshi Miwa M.D.
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Harasawa, S., Tani, N., Suzuki, S. et al. Gastric emptying in normal subjects and patients with peptic ulcer. Gastroenterol Jpn 14, 1–10 (1979). https://doi.org/10.1007/BF02774597

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  • DOI: https://doi.org/10.1007/BF02774597

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