Gastroenterologia Japonica

, Volume 21, Issue 3, pp 213–219 | Cite as

Cholinergic effects of histamine-H2 receptor antagonists partly through inhibition of acetylcholinesterase

  • Mitsuru Aono
  • Motoyuki Moriga
  • Kazuhiko Mizuta
  • Hiroaki Narusawa
Original Article


The effects of histamine H2-receptor antagonists on acetylcholinesterase and pseudocholinesterase activity were studied. All H2-antagonists tested inhibited both enzyme activities dose-dependently. The potency of inhibitory activity of H2-antagonists on acetylcholinesterase estimated from median inhibitory dose were in the following order of decreasing activity: ranitidine > TZU-0460 > cimetidine > YM-11170, whereas that on pseudocholinesterase were TZU-0460 > ranitidine > cimetidine > YM-11170.

As the effects derived from the inhibition of acetylcholinesterase by H2-antagonists may affect intestinal motility, we studied ileal muscle contractions. Ranitidine had the most potent stimulating effect on contraction, the pattern of which was similar to physostigmine and was blocked by atropine and morphine. YM-11170 had a weak action on muscle contraction and cholinesterase activities.

Key Words

Acetylcholine Acetylcholinesterase H2-antagonist Guinea-pig ileum 


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Copyright information

© The Japanese Society of Gastroenterology 1986

Authors and Affiliations

  • Mitsuru Aono
    • 1
  • Motoyuki Moriga
    • 2
  • Kazuhiko Mizuta
    • 2
  • Hiroaki Narusawa
    • 2
  1. 1.Department of Clinical NutritionKyoto University School of MedicineKyotoJapan
  2. 2.First Department of Internal MedicineKyoto University School of MedicineKyotoJapan

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