Summary
Estradiol receptors in the cytosol of peripheral blood mononuclear cells and the effects of interferon-α (IFN-α) on estradiol receptors were studied in asymptomatic hepatitis B virus (HBV) carriers, patients with chronic hepatitis B and normal controls. The level of estradiol receptors in the cytosol of mononuclear cells was significantly lower in asymptomatic HBV carriers and patients with chronic hepatitis B, compared to normal controls. This low level of cytosol estradiol receptors in patients with chronic hepatitis B was increased by the administration of IFN-α. In addition, when peripheral blood mononuclear cells from patients with chronic hepatitis B were incubated with IFN-αvitro, the level of cytosol estradiol receptors also increased by increasing the concentration of IFN-α. We previously reported that the response of mononuclear cells to estrogen is impaired in HBV carriers, and our present results suggested that this may be due to the low level of estradiol receptors in the cytosol of mononuclear cells.
Similar content being viewed by others
References
Butterworth M, McClellan B, Allansmith M: Influence of sex on immunoglobulin levels. Nature 1967; 214:1224–1225
Terres G, Morrison SL, Habicht GS: A quantitative difference in the immune response between male and female mice. Proc Soc Exp Biol Med 1968;127:664–667
Kenny JF, Pangburn PC, Trail G: Effect of estradiol on immune competence:In vitro andin vivo studies. Infect Immune 1967;13:448–456
Castro JE: The hormonal mechanism of immunopotentiation in mice after orchidectomy. J Endocrinol 1974;62:311–318
Ikemoto Y, Mizoguchi Y, Sawai H, et al: Modulation of antibody response by sex hormones. Jpn J Gastroenterol 1983;80:2404–2413 (in Jpn)
Sherlock S: Active chronic hepatitis. In: Gall EA, Mostofi FK, eds. The liver. Williams and Wilkins, Baltimore. 1973:342–360
Amsbaugh DF, Hansen CT, Prescott B, et al: Genetic control of the antibody response to type III Pneumococcal polysaccharide in mice. J Exp Med 1972;136:931–949
Grundbacher FJ: Human X chromosome carries quantitative genes for immunoglobulin M. Science 1972;176:311–312
Mizoguchi Y, Ikemoto Y, Yamamoto S, et al: Studies on the asymptomatic HB virus carriers. Hepato-gastroenterol 1985;32:109–112
Mizoguchi Y, Takeda H, Sakagami Y, et al: Estradiol binding capacity of peripheral blood mononuclear cells in asymptomatic HBV carriers. Hepato-gastroenterol 1987;34:145–147
Yamamoto S, Mizoguchi Y, Ikemoto Y, et al: Studies on the effect of estrogen on the antibody response in the asymptomatic HBV carrier. Jpn J Medicine 1984;23:397
Matuo M: Clinical evaluation of HBeAg/anti-HBe system in HBeAg-positive chronic hepatitis. Acta Hepat Jap 1985;26:819–829(in Jpn)
Mizoguchi Y, Takeda H, Sakagami Y, et al: Effects of interleukin 2 on estradiol binding capacity of peripheral blood mononuclear cells in asymptomatic HBV carriers. Hepato-gastroenterol 1987;34:203–205
Sato B: Modulation of functions of steroid receptor. Horumon To Rinshyo 1981;29:71–77 (in Jpn)
Sato B, Huseby RA, Samuels LT: Evidence of a small molecule in mouse Leydig cell tumors which inhibits the conversion of estrogen receptor from 4S to 5S. Endocrinology 1978,102:545–555
Sato B, Huseby RA, Samuels LT: Characterization of estrogen receptors in various mouse Leydig cell tumor lines. Cancer Res 1978;38:2842–2847
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mizoguchi, Y., Takeda, H., Sakagami, Y. et al. Estradiol receptors in the cytosol of peripheral blood mononuclear cells in hepatitis B virus carriers treated with interferon-α. Gastroenterol Jpn 24, 373–377 (1989). https://doi.org/10.1007/BF02774342
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02774342